DNA end resection during homologous recombination
| Autor: | Robert Gnügge, Lorraine S. Symington |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
DNA Repair
biology fungi Cell DNA Helicases Helicase DNA Genome Article Resection Cell biology chemistry.chemical_compound medicine.anatomical_structure chemistry Dsb repair Genetics biology.protein medicine DNA Breaks Double-Stranded Homologous Recombination Homologous recombination Cell survival Developmental Biology |
| Zdroj: | Curr Opin Genet Dev |
| ISSN: | 0959-437X |
| DOI: | 10.1016/j.gde.2021.07.004 |
| Popis: | Exposure to environmental mutagens but also cell-endogenous processes can create DNA double-strand breaks (DSBs) in a cell's genome. DSBs need to be repaired accurately and timely to ensure genomic integrity and cell survival. One major DSB repair mechanism, called homologous recombination, relies on the nucleolytic degradation of the 5'-terminated strands in a process termed end resection. Here, we review new insights into end resection with a focus on the mechanistic interplay of the nucleases, helicases, and accessory factors involved. |
| Databáze: | OpenAIRE |
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