A Case of Fever and Erythema Nodosum-Like Lesions Leading to a New Diagnosis of Gamma-Delta T-Cell Lymphoma Complicated by Hemophagocytic Lymphohistiocytosis
| Autor: | Jennifer E. Yeh, Joseph C. Kvedar, Aliyah R. Sohani, William Murphy, Rosalynn M. Nazarian, Daniela Kroshinsky |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Erythema nodosum
Pathology medicine.medical_specialty Hemophagocytic lymphohistiocytosis Vincristine Cyclophosphamide business.industry Cutaneous T-cell lymphoma erythema nodosum mimic lcsh:RL1-803 medicine.disease Clinico-Pathological Correlation in Dermatopathology Lymphoma cutaneous t-cell lymphoma hemophagocytic lymphohistiocytosis Subcutaneous nodule medicine lcsh:Dermatology na Panniculitis business skin and connective tissue diseases gamma-delta t-cell lymphoma medicine.drug |
| Zdroj: | Dermatopathology, Vol 6, Iss 4, Pp 266-270 (2020) Dermatopathology Volume 6 Issue 4 Pages 266-270 |
| ISSN: | 2296-3529 |
| Popis: | A 69-year-old Vietnamese female presented with fever and new-onset tender subcutaneous nodules on her trunk and lower extremities initially thought to be clinically consistent with erythema nodosum. A biopsy showed an atypical, predominantly lobular lymphocytic panniculitis with admixed neutrophils, karyorrhectic debris, and histiocytes with subcutaneous fat necrosis. Immunohistochemistry was consistent with gamma-delta T-cell lymphoma. The patient was initiated on a chemotherapy regimen of cyclophosphamide, doxorubicin, vincristine, etoposide, and prednisone (CHOEP) with partial remission, and is currently undergoing evaluation for bone marrow transplant. This case highlights the ability of cutaneous gamma-delta T-cell lymphoma to mimic more common cutaneous conditions such as erythema nodosum, and stresses the importance of a broad differential for new presentation of tender subcutaneous nodules with concomitant systemic symptoms. |
| Databáze: | OpenAIRE |
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