Combined administration of RG7652, a recombinant human monoclonal antibody against PCSK9, and atorvastatin does not result in reduction of immune function
| Autor: | Wendy G. Halpern, Maya Leabman, Jennifer Chilton, Roy Erwin, Thomas Gelzleichter, Abigail S. Forrest, Christina M. Satterwhite, Dale Stevens, Amos Baruch, Kun Peng |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.drug_class medicine.medical_treatment Atorvastatin Immunotoxicology Pharmacology Biology Toxicology Monoclonal antibody Antibodies Monoclonal Humanized chemistry.chemical_compound Subcutaneous injection Immune system medicine Animals Hypersensitivity Delayed Pyrroles Cholesterol PCSK9 Anticholesteremic Agents Serine Endopeptidases Antibodies Monoclonal Immunosuppression Recombinant Proteins Macaca fascicularis chemistry Heptanoic Acids Female Proprotein Convertases Proprotein Convertase 9 medicine.drug |
| Zdroj: | Toxicological sciences : an official journal of the Society of Toxicology. 140(2) |
| ISSN: | 1096-0929 |
| Popis: | RG7652 is a human IgG1 monoclonal antibody designed to inhibit proprotein convertase subtilisin/kexin type 9 (PCSK9) binding to hepatic low density lipoprotein receptor (LDL-r), thereby blocking PCSK9-mediated degradation of LDL-r. This therapeutic candidate is under development for the prevention of cardiovascular mortality and morbidity in dyslipidemic patients. The primary objective of this study was to evaluate the potential immunotoxicological effects of RG7652 when given to cynomolgus monkeys either alone or in combination with a daily oral dose of atorvastatin. Administration of RG7652 via subcutaneous injection every other week for 12 weeks (a total of seven doses), daily oral doses of atorvastatin (total of 85 doses), and combinations of each up to 15 and 20 mg/kg/dose, respectively, were well tolerated and there was no evidence of alteration in immune function. Administration of pharmacologically relevant doses of RG7652 in combination with atorvastatin to healthy monkeys does not result in clinically meaningful immunosuppression as measured by T-cell dependent antibody responses, natural killer cell activity, immunophenotype, or delayed type hypersensitivity. The only pharmacologically mediated changes observed during the dosing period were the anticipated changes in circulating cholesterol. |
| Databáze: | OpenAIRE |
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