Amelioration of hydroxyurea-induced suppression of phagocytosis in human granulocytes by free radical scavengers
| Autor: | Izabella Szczepańnska, Ewa Sitarska, Janina Malec, Jolanta Kwiatkowska, Waldemar M. Przybyszewski |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Free Radicals
Phagocytosis Ascorbic Acid Pharmacology Benzoates Antioxidants Superoxide dismutase chemistry.chemical_compound Humans Hydroxyurea Vitamin E Cytotoxicity Peroxidase Aspirin biology Superoxide Dismutase Hematology Benzoic Acid Catalase Ascorbic acid In vitro Isoenzymes Peroxidases chemistry Biochemistry Depression Chemical biology.protein Sodium benzoate Granulocytes |
| Zdroj: | Scandinavian Journal of Haematology. 34:35-38 |
| ISSN: | 0036-553X |
| DOI: | 10.1111/j.1600-0609.1985.tb00741.x |
| Popis: | The exposure of human circulatory white cells in vitro to 0.1-1-10 mol/l hydroxyurea (HU) for 20 h induced a progressive dose-dependent suppression of the phagocytic activity of granulocytes. The suppressing effect of 20 h exposure to 1 mol/l HU was used to examine the protection afforded by free radical scavengers against HU-induced cytotoxicity. It has been found that, in the suitable concentration of the protecting agent, a substantial protective effect of sodium benzoate, acetylosalicylic acid, alpha-tocopherol, ascorbic acid, catalase, peroxidase or superoxide dismutase can be achieved. |
| Databáze: | OpenAIRE |
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