The genetics of feto-placental development: A study of acid phosphatase locus 1 and adenosine deaminase polymorphisms in a consecutive series of newborn infants

Autor: Gloria, F, Pietropolli, A, Coppeta, L, Magrini, A, Bergamaschi, A, Bottini, E, Coppetta, L
Jazyk: angličtina
Rok vydání: 2008
Předmět:
Male
Adenosine Deaminase
Placenta
gel electrophoresis
Cohort Studies
Fetal Development
placenta development
Endocrinology
Adenosine deaminase
Gene Frequency
newborn
Pregnancy
lcsh:Reproduction
genetic polymorphism
Birth Weight
genetics
Genetics
biology
adult
development and aging
allele
article
Obstetrics and Gynecology
organ size
cohort analysis
fetus
medicine.anatomical_structure
female
Italy
acid phosphatase
Maternal-Fetal Relations
isoprotein
Maternal Age
Gene isoform
medicine.medical_specialty
lcsh:QH471-489
gene locus
phenotype
Birth weight
growth
Locus (genetics)
Caucasian
lcsh:Gynecology and obstetrics
reproduction
Settore MED/44 - MEDICINA DEL LAVORO
Genetic
gestation period
Internal medicine
medicine
Humans
controlled study
human
Allele
Polymorphism
Allele frequency
development
lcsh:RG1-991
Polymorphism
Genetic
Research
Infant
Newborn
Acid phosphatase
Infant
developmental genetics
Placentation
Reproductive Medicine
placenta weight
mother fetus relationship
biology.protein
fetus development
fetoplacental unit
Settore MED/40 - Ginecologia e Ostetricia
homozygosity
population research
Developmental Biology
adenosine deaminase
birth weight
infant
male
gene frequency
growth
development and aging
maternal age
placenta
pregnancy
Acid Phosphatase
Adult
Female
Organ Size
Zdroj: Reproductive Biology and Endocrinology, Vol 6, Iss 1, p 38 (2008)
Reproductive biology and endocrinology : RB&E
Popis: Background Acid phosphatase locus 1 and adenosine deaminase locus 1 polymorphisms show cooperative effects on glucose metabolism and immunological functions. The recent observation of cooperation between the two systems on susceptibility to repeated spontaneous miscarriage prompted us to search for possible interactional effects between these genes and the correlation between birth weight and placental weight. Deviation from a balanced development of the feto-placental unit has been found to be associated with perinatal morbidity and mortality and with cardiovascular diseases in adulthood. Methods We examined 400 consecutive newborns from the Caucasian population of Rome. Birth weight, placental weight, and gestational length were registered. Acid phosphatase locus 1 and adenosine deaminase locus 1 phenotypes were determined by starch gel electrophoresis and correlation analysis was performed by SPSS programs. Informed verbal consent to participate in the study was obtained from the mothers. Results Highly significant differences in birth weight-placental weight correlations were observed among acid phosphatase locus 1 phenotypes (p = 0.005). The correlation between birth weight and placental weight was markedly elevated in subjects carrying acid phosphatase locus 1 phenotypes with medium-low F isoform concentration (A, CA and CB phenotypes) compared to those carrying acid phosphatase locus 1 phenotypes with medium-high F isoform concentration (BA and B phenotypes) (p = 0.002). Environmental and developmental variables were found to exert a significant effect on birth weight-placental weight correlation in subjects with medium-high F isoform concentrations, but only a marginal effect was observed in those with medium-low F isoform concentrations. The correlation between birth weight and placental weight is higher among carriers of the adenosine deaminase locus 1 allele*2, which is associated with low activity, than in homozygous adenosine deaminase locus 1 phenotype 1 carriers (p = 0.04). The two systems show a cooperative effect on the correlation between birth weight and placental weight: the highest value is observed in newborns carrying adenosine deaminase locus 1 allele*2 and acid phosphatase locus 1 phenotypes with medium-low F isoform concentration (p = 0.005). Conclusion These data suggest that zygotes with low adenosine deaminase locus 1 activity and low F activity may experience the most favourable intrauterine conditions for a balanced development of the feto-placental unit.
Databáze: OpenAIRE
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