Bisphosphonate-related osteonecrosis of the jaw: a review of the potential efficacy of low-level laser therapy
| Autor: | Sophiya S. Latifyan, Marie-Thérèse Genot, Jean Klastersky |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment 03 medical and health sciences 0302 clinical medicine Mucositis Medicine Humans Prospective Studies Stage (cooking) Low-Level Light Therapy Low level laser therapy Chemotherapy business.industry Cancer 030206 dentistry Bisphosphonate Middle Aged medicine.disease Surgery Denosumab Oncology 030220 oncology & carcinogenesis Quality of Life Bisphosphonate-Associated Osteonecrosis of the Jaw Female business Osteonecrosis of the jaw medicine.drug |
| Zdroj: | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 24(9) |
| ISSN: | 1433-7339 |
| Popis: | Osteonecrosis of the jaw (ONJ) resulting from administration of bisphosphonates (BP) or denosumab is a rare but severe complication in cancer patients. Complete remission depends on the stage of ONJ; it can be estimated in the range of 20–30 %. Low-level laser therapy (LLLT) is a logical additional option, as it has been recognized effective for the management of chemotherapy and/or radiotherapy-induced mucositis. LLLT irradiation has anti-inflammatory actions and thus can help to control pain, as well as biostimulating properties with favorable actions on bacterial control and wound healing. We review the results of seven published studies of LLLT in BP-associated ONJ. LLLT results in an overall response rate of 55 % superior to that observed in controls (30 %). Our review suggests that there might be an advantage to add LLLT to the “classical” management of ONJ. This therapy is easy to administer and is not associated with any known side effects. Further research is needed to remove any doubt of protection or enhancement of carcinogenic processes. We believe that prospective well-controlled studies of LLLT in ONJ are warranted. If the positive results are confirmed, it would represent a great improvement for the quality of life of many patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink