Noise exposure alters cyclooxygenase 1 (COX-1) and 5-lipoxygenase (5-LO) expression in the guinea pig cochlea

Autor:	Wolf J. Mann, Irene Schmidtmann, Ulf-Rüdiger Heinrich, Ralph Feltens, Oxana Selivanova, Jürgen Brieger
Rok vydání:	2010
Předmět:	Male Pathology medicine.medical_specialty Guinea Pigs Down-Regulation Spiral Lamina Immunoenzyme Techniques Guinea pig chemistry.chemical_compound Nerve Fibers Internal medicine otorhinolaryngologic diseases medicine Animals Humans Inner ear Prospective Studies Organ of Corti Spiral ganglion Cochlea Arachidonate 5-Lipoxygenase Arachidonic Acid biology Stria Vascularis General Medicine Up-Regulation medicine.anatomical_structure Endocrinology Hearing Loss Noise-Induced chemistry Otorhinolaryngology Arachidonate 5-lipoxygenase Cyclooxygenase 1 biology.protein Spiral Ligament of Cochlea Arachidonic acid Schwann Cells sense organs Cyclooxygenase Spiral Ganglion
Zdroj:	Acta Oto-Laryngologica. 130:358-365
ISSN:	1651-2251 0001-6489
DOI:	10.3109/00016480903168066
Popis:	Changes in the metabolism of arachidonic acid (AA) might be part of a noise-induced compensatory mechanism with regional specificity.The released imbalance of prostaglandins and leukotrienes, both AA metabolites, might result in altered blood flow regulation in the inner ear and probably contributes to noise-induced hearing loss. The aim of this study was to gain further information about noise-dependent changes in AA metabolism in the mammalian cochlea.In this prospective animal study, 10 male guinea pigs were exposed to tone bursts for 1 h at 70 dB sound pressure level (SPL) (n = 5) or 90 dB SPL (n = 5). Five animals were used as controls. Alterations in cyclooxygenase 1 (COX-1) and 5-lipoxygenase (5-LO) expression were determined by quantitative immunohistochemical analysis in 11 cochlear regions.COX-1 expression was decreased after both 70 dB SPL and 90 dB SPL exposure in most cell types of the organ of Corti and increased in the nerve fibers of the osseous spiral lamina. 5-LO was lowered after 90 dB SPL exposure, preferentially in the third cochlear turn in the organ of Corti, in the first and second turn in spiral ganglion cells, and in all turns in the stria vascularis.
Databáze:	OpenAIRE
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