Improving the 'real life' management of schizophrenia spectrum disorders by LAI antipsychotics: A one-year mirror-image retrospective study in community mental health services

Autor: Michele Gattullo, Gaetano Nappi, Antonio Emmanuele Uva, Giovanni Carrieri, Apostolos Papazacharias, Domenico Semisa, Maria Lorusso, Enrico D'Ambrosio, Antonia Spinelli, Valeria Latorre, Paola Clemente
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Critical Care and Emergency Medicine
Economics
viruses
Social Sciences
0302 clinical medicine
Management of schizophrenia
immune system diseases
Outpatients
Medicine and Health Sciences
Medicine
Antipsychotics
Spectrum disorder
030212 general & internal medicine
Multidisciplinary
Drugs
virus diseases
Community Mental Health Services
Hospitals
Hospitalization
Treatment Outcome
Schizophrenia
Female
Antipsychotic Agents
Research Article
Adult
medicine.medical_specialty
Patients
Science
Injections
03 medical and health sciences
Health Economics
Mental Health and Psychiatry
Humans
Psychiatry
Quality of Health Care
Retrospective Studies
Pharmacology
Hospitalizations
Health economics
business.industry
Retrospective cohort study
medicine.disease
Mental health
Health Care
Health Care Facilities
Observational study
business
030217 neurology & neurosurgery
Diagnosis of schizophrenia
Zdroj: PLoS ONE, Vol 15, Iss 3, p e0230051 (2020)
PLoS ONE
ISSN: 1932-6203
Popis: Schizophrenia poses a significant economic burden on the healthcare system as well as it has a significant impact on society at large. Reasons for such a high economic burden of schizophrenia include the frequent relapses and hospitalizations occurring in this disorder. We analyze the effectiveness of long-acting injectable antipsychotics (LAIs) compared to oral medications, in terms of "clinical process management" in a sample of patients with a diagnosis of schizophrenia spectrum disorder treated in community mental health centers. An observational, retrospective, mirror-image study was carried out to evaluate the effectiveness of LAIs compared to oral medications in terms of number of hospitalizations, emergency visits and planned visits on a 10-year period (from July 2007 to June 2017). Differences between first and second generation LAIs were also explored. Our findings show that hospitalization and emergency visits are significantly decreased with the use of LAIs, while planned visits are increased in patients treated with LAIs. Our results suggest that LAIs, in particular, second generation ones, reduce hospitalization rates and emergency visits, improving the economic burden of schizophrenia. Therefore, LAIs should be considered a cost-effective treatment in the management of schizophrenia under routine conditions.
Databáze: OpenAIRE
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