Improving the 'real life' management of schizophrenia spectrum disorders by LAI antipsychotics: A one-year mirror-image retrospective study in community mental health services
Autor: | Michele Gattullo, Gaetano Nappi, Antonio Emmanuele Uva, Giovanni Carrieri, Apostolos Papazacharias, Domenico Semisa, Maria Lorusso, Enrico D'Ambrosio, Antonia Spinelli, Valeria Latorre, Paola Clemente |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Male
Critical Care and Emergency Medicine Economics viruses Social Sciences 0302 clinical medicine Management of schizophrenia immune system diseases Outpatients Medicine and Health Sciences Medicine Antipsychotics Spectrum disorder 030212 general & internal medicine Multidisciplinary Drugs virus diseases Community Mental Health Services Hospitals Hospitalization Treatment Outcome Schizophrenia Female Antipsychotic Agents Research Article Adult medicine.medical_specialty Patients Science Injections 03 medical and health sciences Health Economics Mental Health and Psychiatry Humans Psychiatry Quality of Health Care Retrospective Studies Pharmacology Hospitalizations Health economics business.industry Retrospective cohort study medicine.disease Mental health Health Care Health Care Facilities Observational study business 030217 neurology & neurosurgery Diagnosis of schizophrenia |
Zdroj: | PLoS ONE, Vol 15, Iss 3, p e0230051 (2020) PLoS ONE |
ISSN: | 1932-6203 |
Popis: | Schizophrenia poses a significant economic burden on the healthcare system as well as it has a significant impact on society at large. Reasons for such a high economic burden of schizophrenia include the frequent relapses and hospitalizations occurring in this disorder. We analyze the effectiveness of long-acting injectable antipsychotics (LAIs) compared to oral medications, in terms of "clinical process management" in a sample of patients with a diagnosis of schizophrenia spectrum disorder treated in community mental health centers. An observational, retrospective, mirror-image study was carried out to evaluate the effectiveness of LAIs compared to oral medications in terms of number of hospitalizations, emergency visits and planned visits on a 10-year period (from July 2007 to June 2017). Differences between first and second generation LAIs were also explored. Our findings show that hospitalization and emergency visits are significantly decreased with the use of LAIs, while planned visits are increased in patients treated with LAIs. Our results suggest that LAIs, in particular, second generation ones, reduce hospitalization rates and emergency visits, improving the economic burden of schizophrenia. Therefore, LAIs should be considered a cost-effective treatment in the management of schizophrenia under routine conditions. |
Databáze: | OpenAIRE |
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