Acute Q fever in third trimester pregnancy
| Autor: | Suji Prabhaharan, Marion L. Woods, Maxwell Braddick |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Pregnancy Trimester Third Drug intolerance Q fever Pregnancy Internal medicine Clarithromycin Trimethoprim Sulfamethoxazole Drug Combination Humans Medicine Pregnancy Complications Infectious Hepatitis biology business.industry General Medicine bacterial infections and mycoses medicine.disease Coxiella burnetii biology.organism_classification Trimethoprim Gestation Female Q Fever business medicine.drug |
| Zdroj: | BMJ Case Reports. 14:e242558 |
| ISSN: | 1757-790X |
| DOI: | 10.1136/bcr-2021-242558 |
| Popis: | A 29-year-old gravida 2 para 1 woman presented at 29 weeks gestation with fevers, back pain, thrombocytopenia and hepatitis. PCR testing of blood samples detected Coxiella burnetii and paired serology later confirmed the diagnosis of acute Q fever in pregnancy. The patient was treated empirically with oral clarithromycin and experienced a symptomatic and biochemical improvement. Therapy was changed to oral trimethoprim/sulphamethoxazole but was complicated by a delayed cutaneous reaction, prompting recommencement of clarithromycin. Therapy continued until delivery of a healthy girl at 39 weeks and 3 days. Q fever in pregnancy is likely under-reported and is associated with the development of chronic infection and obstetric complications. Treatment with clarithromycin is an alternative to trimethoprim/sulphamethoxazole in the setting of drug intolerance. |
| Databáze: | OpenAIRE |
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