EARLY CHOLINE LEVELS FROM 3-TESLA MR SPECTROSCOPY AFTER EXCLUSIVE RADIATION THERAPY IN PATIENTS WITH CLINICALLY LOCALIZED PROSTATE CANCER ARE PREDICTIVE OF PLASMATIC LEVELS OF PSA AT 1 YEAR
| Autor: | Sébastien Parfait, Céline Mirjolet, Mélanie Gauthier, Franck Bonnetain, Philippe Maingon, Alexandre Cochet, Paul Walker, François Brunotte, Gilles Créhange, Luc Cormier |
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| Přispěvatelé: | Centre Régional de Lutte contre le cancer - Centre Georges-François Leclerc ( CRLCC - CGFL ), Laboratoire Electronique, Informatique et Image ( Le2i ), Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique ( CNRS ), Centre d'épidémiologie des populations ( CEP ), Université de Bourgogne ( UB ) -Centre Régional de Lutte contre le cancer - Centre Georges-François Leclerc ( CRLCC - CGFL ), Service d'urologie, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER, Laboratoire Electronique, Informatique et Image [UMR6306] (Le2i), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Arts et Métiers (ENSAM), Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM)-Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Centre d'épidémiologie des populations (CEP), Université de Bourgogne (UB)-Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER, Service d'Urologie [CHU de Dijon], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Université de Bourgogne (UB)-École Nationale Supérieure d'Arts et Métiers (ENSAM), HESAM Université (HESAM)-HESAM Université (HESAM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
In vivo magnetic resonance spectroscopy Cancer Research Time Factors medicine.medical_treatment Choline 030218 nuclear medicine & medical imaging chemistry.chemical_compound Prostate cancer 0302 clinical medicine Prostate Prospective Studies Prospective cohort study Radiation [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging Organ Size Middle Aged Tumor Burden medicine.anatomical_structure Oncology Chemotherapy Adjuvant 030220 oncology & carcinogenesis Predictive value of tests Hormonal therapy Response monitoring medicine.medical_specialty Urology Citric Acid 03 medical and health sciences Body Water Predictive Value of Tests Magnetic resonance spectroscopy medicine [INFO.INFO-IM]Computer Science [cs]/Medical Imaging Humans Radiology Nuclear Medicine and imaging Aged business.industry Prostatic Neoplasms Androgen Antagonists Prostate-Specific Antigen medicine.disease Radiation therapy chemistry Radiotherapy Intensity-Modulated 3 Tesla business Nuclear medicine |
| Zdroj: | International Journal of Radiation Oncology Biology Physics International Journal of Radiation Oncology Biology Physics, 2011, 81 (4), pp.E407-413. 〈10.1016/j.ijrobp.2011.03.008〉 International Journal of Radiation Oncology-Biology-Physics International Journal of Radiation Oncology-Biology-Physics, Elsevier, 2011, 81 (4), pp.E407-413. ⟨10.1016/j.ijrobp.2011.03.008⟩ |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/j.ijrobp.2011.03.008〉 |
| Popis: | International audience; Abstract: Purpose: To investigate the time course response of prostate metabolism to irradiation using magnetic resonance spectroscopy (MRS) at 3-month intervals and its impact on biochemical control. Methods and Materials: Between January 2008 and April 2010, 24 patients with localized prostate cancer were prospectively enrolled in the Evaluation of the Response to Irradiation with MR Spectroscopy (ERIS) trial. All the patients had been treated with intensity-modulated radiation therapy with or without long-term adjuvant hormonal therapy (LTHT) and underwent 3-T MRS and prostate-specific antigen (PSA) assays at baseline and every 3 months thereafter up to 12 months. Results: After radiation, the mean normalized citrate level (citrate/water) decreased significantly over time, both in the peripheral zone (PZ) (p = 0.0034) and in the entire prostate (p = 0.0008), whereas no significant change was observed in mean normalized choline levels (choline/water) in the PZ (p = 0.84) and in the entire prostate (p = 0.95). At 6 months after radiation, the mean choline level was significantly lower in the PZ for patients with a PSAvalue of |
| Databáze: | OpenAIRE |
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