Randomized, placebo-controlled trial of combination antiemetic prophylaxis for day-case gynaecological laparoscopic surgery
| Autor: | J.P. Curran, G J Hobbs, A.B. Ahmed |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Antiemetic Agent medicine.medical_specialty medicine.drug_class Nausea Placebo-controlled study Ondansetron Double-Blind Method medicine Cyclizine Antiemetic Humans business.industry Surgery Anesthesiology and Pain Medicine Treatment Outcome Ambulatory Surgical Procedures Anesthesia Postoperative Nausea and Vomiting Vomiting Histamine H1 Antagonists Antiemetics Drug Therapy Combination Female Laparoscopy Serotonin Antagonists medicine.symptom business Postoperative nausea and vomiting medicine.drug |
| Zdroj: | British journal of anaesthesia. 85(5) |
| ISSN: | 0007-0912 |
| Popis: | In a randomized, double-blind trial, we compared i.v. ondansetron 4 mg (control), i.v. ondansetron 4 mg and cyclizine 50 mg (combination) and i.v. saline 0.9% (placebo), given after induction of standardized anaesthesia, for the prevention of nausea and vomiting (PONV) after day-case gynaecological laparoscopic surgery. Compared with placebo, fewer patients in the control group vomited (9/20 versus 11/59, P = 0.02) or needed rescue antiemetic (7/20 versus 9/59, P = 0.06) before discharge. Compared with the control, fewer patients in the combination group (n = 60) vomited (11/59 versus 2/60, P = 0.01) or needed rescue antiemetic (29/59 versus 2/60, P = 0.03) before discharge. The incidence of vomiting in the combination group was less than 5% overall. Compared with the control, the combination group had a significantly lower incidence (P = 0.001) and severity (P0.001) of nausea after discharge and more patients with no PONV at any time during the study (15/59 versus 27/60, P = 0.03). Unlike the placebo and control groups, no patient receiving combination prophylaxis was admitted overnight for PONV management. |
| Databáze: | OpenAIRE |
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