C1 inhibitor treatment improves host defense in pneumococcal meningitis in rats and mice
| Autor: | A. Marceline van Furth, Machteld M. J. Polfliet, Timo K. van den Berg, Petra J. G. Zwijnenburg, J. J. Roord, C. Erik Hack, Tom van der Poll, Sandrine Florquin, Christine D. Dijkstra |
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| Přispěvatelé: | Amsterdam institute for Infection and Immunity, Infectious diseases, Pathology, General Internal Medicine, Landsteiner Laboratory, Human genetics, Molecular cell biology and Immunology, Clinical chemistry, Internal medicine, Pediatric surgery |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Male
Colony Count Microbial Macrophage-1 Antigen Biology medicine.disease_cause Proinflammatory cytokine C1-inhibitor Sepsis Mice Classical complement pathway Meninges Complement C1 Streptococcus pneumoniae medicine Animals Humans Immunology and Allergy Complement Pathway Classical Rats Wistar Complement Activation Cerebrospinal Fluid Brain Chemistry Innate immune system Meningitis Pneumococcal Brain medicine.disease bacterial infections and mycoses Rats Complement system Mice Inbred C57BL Disease Models Animal Infectious Diseases Immunology biology.protein Cytokines Chemokines Complement C1 Inhibitor Protein Meningitis |
| Zdroj: | Journal of infectious diseases, 196(1), 115-123. Oxford University Press Zwijnenburg, P J G, van der Poll, T, Florquin, S, Polfliet, M M J, van den Berg, T K, Dijkstra, C D, Roord, J J, Hack, C E & van Furth, A M 2007, ' C1 inhibitor treatment improves host defense in pneumococcal meningitis in rats and mice ', Journal of Infectious Diseases, vol. 196, no. 1, pp. 115-23 . https://doi.org/10.1086/518609 Journal of Infectious Diseases, 196(1), 115-23. Oxford University Press |
| ISSN: | 0022-1899 |
| DOI: | 10.1086/518609 |
| Popis: | In spite of antibiotic treatment, pneumococcal meningitis continues to be associated with significant morbidity and mortality. The complement system is a key component of innate immunity against invading pathogens. However, activation of complement is also involved in tissue damage, and complement inhibition by C1 inhibitor (C1-inh) is beneficial in animal models of endotoxemia and sepsis. In the present study, we demonstrate classical pathway complement activation during pneumococcal meningitis in rats. We also evaluate the effect of C1-inh treatment on clinical illness, bacterial clearance, and inflammatory responses in rats and mice with pneumococcal meningitis. C1-inh treatment was associated with reduced clinical illness, a less-pronounced inflammatory infiltrate around the meninges, and lower brain levels of proinflammatory cytokines and chemokines. C1-inh treatment increased bacterial clearance, possibly through an up-regulation of CR3. Hence, C1-inh may be a useful agent in the treatment of pneumococcal meningitis. |
| Databáze: | OpenAIRE |
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