Phylogenomic analysis of SARS-CoV-2 from third wave clusters in Malaysia reveals dominant local lineage B.1.524 and persistent spike mutation A701V
| Autor: | Ravindran Thayan, H Yahya, Z Mohd-Zawawi, S A Md-Hanif, M A Afizan, J Suppiah, K A Kamel |
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| Rok vydání: | 2021 |
| Předmět: |
Lineage (genetic)
Coronavirus disease 2019 (COVID-19) SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Malaysia virus diseases COVID-19 Biology Genome Phylogenetics Evolutionary biology parasitic diseases Mutation (genetic algorithm) Spike Glycoprotein Coronavirus Humans Spike (database) Third wave Phylogeny |
| Zdroj: | Tropical biomedicine. 38(3) |
| ISSN: | 2521-9855 |
| Popis: | The emergence of a third wave of COVID-19 infection in Malaysia since September 2020 has led to imminent changes in public health prevention and control measures. As high as 96.2% of registered COVID-19 cases and 88.5% of confirmed deaths in Malaysia occurred during this third wave of infection. A phylogenomic study on 258 SARS-CoV-2 full genomes from February 2020-February 2021 has led to the discovery of a novel Malaysian lineage B.1.524. This lineage contains another spike mutation A701V that co-exists with the D614G spike mutation that was predominant in most of the third-wave clusters. The study provides vital genomic insights on the rapid spread of the SARS-CoV-2 variants in Malaysia in conjunction with the presence of a dominant SARS-CoV-2 lineage during the third wave of COVID-19 infection. |
| Databáze: | OpenAIRE |
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