Pyridazine N-Oxides as Precursors to 2-Aminofurans: Scope and Limitations in Complexity Building Cascade Reactions
| Autor: | Maribel Borger, James H. Frederich |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
biology
Scope (project management) 010405 organic chemistry Chemistry Organic Chemistry Synthon 010402 general chemistry biology.organism_classification 01 natural sciences Biochemistry Combinatorial chemistry Article 0104 chemical sciences Catalysis Pyridazine chemistry.chemical_compound Cascade Aspidosperma Reactivity (chemistry) Physical and Theoretical Chemistry Amaryllidaceae Alkaloids |
| Zdroj: | Org Lett |
| ISSN: | 1523-7052 1523-7060 |
| Popis: | A method to transform pyridazine N-oxides into 2-aminofurans using a combination of UV light and transition metal catalysis has been developed. These electron-rich species exhibit a surprising range of useful reactivity, including the ability to participate in complexity building cascade processes when reacted with dienophiles. This study also establishes 2-aminofurans as valuable synthons that support modular synthetic entry to the shared heterocyclic core of certain aspidosperma and amaryllidaceae alkaloids. |
| Databáze: | OpenAIRE |
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