The serum half-life and urine concentrations of cephazolin sodium in patients with terminal renal failure: effect of haemodialysis
| Autor: | P. E. Gower, J.R. Curtis, J. B. Eastwood |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Adult
Male Time Factors Urine Dialysis patients chemistry.chemical_compound Renal Dialysis Cefazolin Medicine Humans In patient Creatinine business.industry Maintenance haemodialysis Dosing regimen Cephazolin sodium Half-life General Medicine Middle Aged Cephalosporins chemistry Anesthesia Injections Intravenous Kidney Failure Chronic Female business Half-Life |
| Zdroj: | Scottish medical journal. 20(5) |
| ISSN: | 0036-9330 |
| Popis: | The serum and plasma half-life of cephazolin has been determined in 5 maintenance haemodialysis patients during a non-dialysis period and then again in the same patients during haemodialysis with a Meltec Maxi-Multipoint dialyser using cuprophane membranes. The mean half-life during the non-dialysis period was 28.3 hours and fell to a mean of 4.97 hours during haemodialysis. Percentage recovery of cephazolin in the urine was markedly reduced in 4 maintenance dialysis patients although adequate urine concentrations of cephazolin were achieved for many sensitive organisms. A dosage schedule for patients with creatinine clearances of less than 5 ml. per minute and for maintenance haemodialysis patients is suggested. |
| Databáze: | OpenAIRE |
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