Platelet α-granules contribute to organ-specific pathologies in a mouse model of severe malaria
| Autor: | Michael P. Schenk, Thayer K. Darling, Chengjing C Zhou, Shawn M. Jobe, Tracey J. Lamb, Jonathan M. Gibbins, Patrice N. Mimche, Franklin M Maloba |
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| Rok vydání: | 2019 |
| Předmět: |
Blood Platelets
0301 basic medicine ARDS Alpha (ethology) Disease Lung injury Cytoplasmic Granules Plasmodium Mice 03 medical and health sciences 0302 clinical medicine parasitic diseases Animals Medicine Platelet biology business.industry Hematology biology.organism_classification medicine.disease Stimulus Report Malaria Disease Models Animal 030104 developmental biology Cerebral Malaria Immunology business 030215 immunology |
| Zdroj: | Blood Advances. 4:1-8 |
| ISSN: | 2473-9537 2473-9529 |
| Popis: | Cerebral malaria (CM) and malaria-associated acute lung injury/acute respiratory distress syndrome (MA-ALI/ARDS) are among the most severe complications of Plasmodium infection. While these disease manifestations are multifactorial, platelets have been described to play a role in the development of both syndromes in humans1,2 and mice3,4. Although the impact of platelets on malaria has been well-studied, questions remains with regard to their contribution to parasite control and immunopathogenesis. Studies have indicated that platelets can kill Plasmodium-infected red blood cells (iRBCs)5-8. However, there are contrasting reports that platelets do not exert any significant control over parasite growth but rather exacerbate malaria immunopathology3,9-12. In this study, we address the role of platelets in the development of severe malaria in three different mouse models of platelet dysfunction/depletion. We show a key role for platelets, and particularly platelet alpha granules (-granules), in mediating organ-specific pathologies during rodent Plasmodium infection. |
| Databáze: | OpenAIRE |
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