Anti-Depressant Properties of Crocin Molecules in Saffron
| Autor: | Shahida Anusha Siddiqui, Ali Ali Redha, Edgar Remmet Snoeck, Shubhra Singh, Jesus Simal-Gandara, Salam A. Ibrahim, Seid Mahdi Jafari |
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| Rok vydání: | 2022 |
| Předmět: |
Biological Products
3209.04 Medicamentos Naturales Plant Extracts Organic Chemistry Pharmaceutical Science Crocus Carotenoids ddc Analytical Chemistry Chemistry (miscellaneous) Drug Discovery Molecular Medicine Physical and Theoretical Chemistry Coloring Agents 5101.13 Medicina Tradicional Review \n saffron crocin natural anti-depressants traditional medicine |
| Zdroj: | Molecules (Basel, Switzerland). 27(7) |
| ISSN: | 1420-3049 |
| Popis: | Saffron is a valued herb, obtained from the stigmas of the C. sativus Linn (Iridaceae), with therapeutic effects. It has been described in pharmacopoeias to be variously acting, including as an anti-depressant, anti-carcinogen, and stimulant agent. The therapeutic effects of saffron are harbored in its bioactive molecules, notably crocins, the subject of this paper. Crocins have been demonstrated to act as a monoamine oxidase type A and B inhibitor. Furthermore, saffron petal extracts have experimentally been shown to impact contractile response in electrical field stimulation. Other research suggests that saffron also inhibits the reuptake of monoamines, exhibits N-methyl-d-aspartate antagonism, and improves brain-derived neurotrophic factor signaling. A host of experimental studies found saffron/crocin to be similarly effective as fluoxetine and imipramine in the treatment of depression disorders. Saffron and crocins propose a natural solution to combat depressive disorders. However, some hurdles, such as stability and delivery, need to be overcome. United States Department of Agriculture | Ref. 2020-38821-31113 National Institute of Food and Agriculture | Ref. NC.X337-5-21-170-1 National Institute of Food and Agriculture | Ref. NC.X341-5-21-170-1 |
| Databáze: | OpenAIRE |
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