Angiotensin converting enzyme polymorphism in type 2 diabetes mellitus
| Autor: | Ana Carolina Bonini Domingos, Edi Carlos Iacida, Luiz Carlos de Mattos, Claudia Regina Bonini-Domingos, Cinara Cássia Brandão de Mattos |
|---|---|
| Přispěvatelé: | Universidade Estadual Paulista (Unesp) |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
type 2 diabetes mellitus type 2 diabet Biomedical Engineering Type 2 diabetes Disease Gastroenterology General Biochemistry Genetics and Molecular Biology Diabetes mellitus Internal medicine Drug Discovery Genotype medicine angiotensin converting enzyme polymorphism genetic polymorphism Allele biology Type 2 Diabetes Mellitus Angiotensin-converting enzyme General Medicine medicine.disease ACE polymorphism Genotype frequency Endocrinology biology.protein I/D polymorphism |
| Zdroj: | Currículo Lattes Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 2214-0247 |
| DOI: | 10.1016/j.bgm.2014.06.001 |
| Popis: | Made available in DSpace on 2015-04-27T11:55:58Z (GMT). No. of bitstreams: 0 Previous issue date: 2014 This study was undertaken to assess the frequency of angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism in patients with type 2 diabetes mellitus. A total of 162 patients with type 2 diabetes and 160 individuals without this disease were analyzed. From the diabetes group, 81 patients with cardiovascular risk (according to American Diabetes Association parameters) were selected to form another subgroup. For polymorphism identification, two polymerase chain reactions were performed: one reaction to identify all genotypes and a second one to confirm the presence of the I allele. The observed genotype frequencies were as follows: diabetes group I/I (19.1%), I/D (52.5%), D/D (28.4%); control group I/I (12.5%), I/D (55.6%), D/D (31.9%); and diabetes with cardiovascular risk group I/I (16.0%), I/ D (59.3%), D/D (24.7%). No statistically significant difference was observed between the allelic and genotypic frequencies in the analyzed groups. Previous studies reported an association between the D allele and type 2 diabetes in Caucasian and East Asian populations. However, in mixed populations, such as those found in Brazil, such an association was not found. This fact does not discard the need for more studies on the frequencies of this polymorphism in the Brazilian population and the associations with risk factors, which can compromise the quality of life of diabetes patients Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Biologia, Instituto de Biociências Letras e Ciências Exatas de São José do Rio Preto, Sao Jose do Rio Preto, Rua Cristóvão Colombo, 2265, Jardim Nazareth, CEP 15054-000, SP, Brasil Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Biologia, Instituto de Biociências Letras e Ciências Exatas de São José do Rio Preto, Sao Jose do Rio Preto, Rua Cristóvão Colombo, 2265, Jardim Nazareth, CEP 15054-000, SP, Brasil |
| Databáze: | OpenAIRE |
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