Scale-up of industrial microbial processes
| Autor: | Jefferson C. Lievense, Jason S Crater |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0106 biological sciences
0301 basic medicine scale-up Guiding Principles Process development Computer science Pilot Projects 01 natural sciences Microbiology 03 medical and health sciences Industrial Microbiology Bioreactors Biotechnology and Synthetic Biology 010608 biotechnology Genetics Production (economics) Molecular Biology Bacteria bioprocessing scale-down Investment (macroeconomics) 030104 developmental biology Risk analysis (engineering) piloting Current Opinion large-scale SCALE-UP Fermentation |
| Zdroj: | FEMS Microbiology Letters |
| ISSN: | 1574-6968 |
| Popis: | Scaling up industrial microbial processes for commercial production is a high-stakes endeavor, requiring time and investment often exceeding that for laboratory microbe and process development. Omissions, oversights and errors can be costly, even fatal to the program. Approached properly, scale-up can be executed successfully. Three guiding principles are provided as a basis: begin with the end in mind; be diligent in the details; prepare for the unexpected. A detailed roadmap builds on these principles. There is a special emphasis on the fermentation step, which is usually the costliest and also impacts downstream processing. Examples of common scale-up mistakes and the recommended approaches are given. It is advised that engineering resources skilled in integrated process development and scale-up be engaged from the very beginning of microbe and process development to guide ongoing R&D, thus ensuring a smooth and profitable path to the large-scale commercial end. Scaling up industrial microbial processes is a costly, high-stakes endeavor that can be executed successfully if approached properly. |
| Databáze: | OpenAIRE |
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