Lectin histochemistry of the esophagus in several mammalian species
| Autor: | Herbert F. Helander, Nadereh Poorkhalkali, Ingemar Jacobson |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Sucrose
Embryology Pathology medicine.medical_specialty Swine Glycoconjugate Fluorescent Antibody Technique Stratified squamous epithelium Dogs Esophagus Pepsin Lectins medicine Animals Humans chemistry.chemical_classification biology Ferrets Lectin Cell Biology Anti-Ulcer Agents Pepsin A Epithelium Staining medicine.anatomical_structure chemistry Cats biology.protein Immunohistochemistry Hydrochloric Acid Rabbits Anatomy Glycoconjugates Developmental Biology |
| Zdroj: | Anatomy and Embryology. 200:541-549 |
| ISSN: | 1432-0568 0340-2061 |
| Popis: | The mucosa of the esophagus consists of stratified squamous epithelium that has a considerable resistance to injury. Intercellular glycoconjugates appear to constitute a major permeability barrier in the superficial portion of the esophageal mucosa. In the present study, we used a panel of lectins to investigate the differences in glycoconjugate production among different mammalian species. A battery of 12 lectins was used to study binding in sections from the esophagus of 6 mammalian species, including man. In general, the strongest staining was obtained in the stratum superficiale and the weakest staining in the stratum germinativum. In rabbit esophagus, exposure to pepsin/HCl produced a superficial damage to the epithelium, a considerable decrease in electrical resistance and a decreased staining of the esophageal epithelium with selected lectins. Pretreatment of the esophageal mucosa with sucrose octasulfate, a compound with protective properties, prevented, to some extent, the decrease in resistance and lectin staining. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink