A high-protein peptide-based enteral formula improves diarrhea in tube-fed patients: A prospective multicenter study

Autor: Sornwichate Rattanachaiwong, Tippawan Siritientong, Veeradej Pisprasert, Pranithi Hongsprabhas, Phitphiboon Deawtrakulchai, Somkit Williams, Naluttaporn Suebsoh, Sidarut Samuksaman, Phayom Bunsut, Pornpoj Pramyothin, Nanta Khumkhana, Pennapa Tipsung, Mayura Vattanapongpisan, Panuwat Promsin
Rok vydání: 2022
Předmět:
Zdroj: Nutrition and health.
ISSN: 0260-1060
2021-0302
Popis: Background Diarrhea is a common problem in tube-fed patients. The relevant guidelines suggest using a peptide-based enteral formula in patients with diarrhea; however, sufficient evidence to support this recommendation is currently lacking. Aim This study aimed to evaluate the effects of a high-protein peptide-based formula on gastrointestinal intolerance, mainly focusing on diarrhea symptoms in patients who were intolerant to polymeric formula feeding. Methods This prospective, single-arm, open-label, multicenter study was conducted from March 2021 to March 2022 at two tertiary-care hospitals. Patients who presented with diarrhea during tube feeding with polymeric formula were assigned to receive a high-protein peptide-based formula for ≤7 days. Stool weight and frequency were monitored at baseline, on day 3, and on day 7 (or end of the study) as the primary outcomes. Results Twenty-eight tube-fed patients with diarrhea were recruited. After switching their feeding formula from polymeric to peptide based, significant improvements in stool frequency and stool weight were observed on day 3 and day 7 compared with the baseline (median [IQR] stool frequency: 5 (2), 2.5 (3.5), and 3 (3) times/day, respectively, p Conclusion A high-protein peptide-based enteral formula was effective in reducing stool weight and frequency in patients who experienced diarrhea during tube feeding with a polymeric formula. Trial registration: TCTR20210302006
Databáze: OpenAIRE
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