Synthesis and biological evaluation of novel alkyl amide functionalized trifluoromethyl substituted pyrazolo[3,4-b]pyridine derivatives as potential anticancer agents
| Autor: | Chityal Ganesh Kumar, Veeraswamy Banda, Sambasiva Rao Pillalamarri, Kurumurthy Chavva, Narsaiah Banda, J. Gaddamedi, Poornachandra Yedla, Santhosh Kumar Gautham |
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| Rok vydání: | 2013 |
| Předmět: |
Molar concentration
Alkylation Halogenation Pyridines Clinical Biochemistry Pharmaceutical Science Antineoplastic Agents Biochemistry chemistry.chemical_compound Structure-Activity Relationship Amide Cell Line Tumor Neoplasms Drug Discovery Pyridine medicine Organic chemistry Humans Molecular Biology Alkyl chemistry.chemical_classification Trifluoromethyl Primary (chemistry) Organic Chemistry Cancer medicine.disease Combinatorial chemistry Amides chemistry Molecular Medicine Pyrazoles |
| Zdroj: | Bioorganicmedicinal chemistry letters. 23(21) |
| ISSN: | 1464-3405 |
| Popis: | A series of novel alkyl amide functionalized trifluoromethyl substituted pyrazolo[3,4-b]pyridine derivatives 5, 6 and 7 were prepared starting from 6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-amine 3 via selective N-alkylation, followed by reaction with different primary aliphatic amines, cyclic secondary amines or l-amino acids under different set of conditions. All the synthesized compounds 5, 6 and 7 were screened for anticancer activity against four cancer cell lines such as A549-Lung cancer (CCL-185), MCF7-Breast cancer (HTB-22), DU145-Prostate cancer (HTB-81) and HeLa-Cervical cancer (CCL-2). The compounds 5i and 6e are found to have promising bioactivity at micro molar concentration. |
| Databáze: | OpenAIRE |
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