Real-Time Label-Free Surface Plasmon Resonance Biosensing with Gold Nanohole Arrays Fabricated by Nanoimprint Lithography
| Autor: | Josu Martinez-Perdiguero, Aritz Juarros, Aritz Retolaza, Santos Merino, Deitze Otaduy |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Materials science
Protein Array Analysis Metal Nanoparticles Physics::Optics Nanotechnology Biosensing Techniques lcsh:Chemical technology biosensor Biochemistry Sensitivity and Specificity label-free Article Analytical Chemistry Nanoimprint lithography law.invention Absorption Molecular Imprinting Nanopores law Computer Systems lcsh:TP1-1185 nanoimprint lithography Electrical and Electronic Engineering Surface plasmon resonance Particle Size Absorption (electromagnetic radiation) Instrumentation surface plasmon resonance nanohole array Staining and Labeling business.industry Reproducibility of Results Equipment Design Atomic and Molecular Physics and Optics Equipment Failure Analysis Nanopore Modulation Optoelectronics Gold business Biosensor Refractive index |
| Zdroj: | Sensors; Volume 13; Issue 10; Pages: 13960-13968 Sensors (Basel, Switzerland) Scopus-Elsevier Sensors, Vol 13, Iss 10, Pp 13960-13968 (2013) |
| ISSN: | 1424-8220 |
| DOI: | 10.3390/s131013960 |
| Popis: | In this work we present a surface plasmon resonance sensor based on enhanced optical transmission through sub-wavelength nanohole arrays. This technique is extremely sensitive to changes in the refractive index of the surrounding medium which result in a modulation of the transmitted light. The periodic gold nanohole array sensors were fabricated by high-throughput thermal nanoimprint lithography. Square periodic arrays with sub-wavelength hole diameters were obtained and characterized. Using solutions with known refractive index, the array sensitivities were obtained. Finally, protein absorption was monitored in real-time demonstrating the label-free biosensing capabilities of the fabricated devices. |
| Databáze: | OpenAIRE |
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