Low-dose human chorionic gonadotropin alone can complete follicle maturity: successful application to modified natural cycle in vitro fertilization
| Autor: | S. Jabara, Kristin Bendikson, Karine Chung, S.J. Mucowski, Richard J. Paulson, Alexander M. Quaas |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
0301 basic medicine Infertility medicine.medical_specialty media_common.quotation_subject Oocyte Retrieval Stimulation Fertility Fertilization in Vitro Chorionic Gonadotropin Human chorionic gonadotropin Andrology 03 medical and health sciences Follicle 0302 clinical medicine Human fertilization Ovarian Follicle Natural cycle in vitro fertilization Pregnancy Internal medicine medicine Humans media_common 030219 obstetrics & reproductive medicine business.industry Obstetrics and Gynecology medicine.disease 030104 developmental biology Endocrinology Reproductive Medicine Ganirelix Acetate Feasibility Studies Female business Infertility Female Live Birth hormones hormone substitutes and hormone antagonists |
| Zdroj: | Fertility and Sterility. 105:1228-1231 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/j.fertnstert.2016.01.021 |
| Popis: | Objective To investigate the feasibility of utilizing low-dose hCG alone to complete follicle maturity in a natural cycle, without the need for antecedent exogenous FSH stimulation. Design Case series. Setting Academic fertility program. Patient(s) Normally ovulatory women with infertility thought to be predominantly due to male factor. Intervention(s) Modified natural IVF cycles were conducted as follows: natural ovulatory cycles were monitored with serial ultrasound examinations and serum E 2 determinations. When the lead follicle reached preovulatory status according to cycle day, ultrasound, and E 2 levels, 0.25 mg of the GnRH antagonist ganirelix acetate was administered along with 200 IU of hCG. These medications were repeated daily for 2 to 3 days with further serial monitoring. A trigger dose of 10,000 IU of hCG was followed by follicle aspiration, IVF, and ET in a standard manner. Main Outcome Measure(s) Follicle maturity, live births, documentation of the feasibility of this new approach. Result(s) In all cases, E 2 levels rose and the dominant follicle continued to increase in size in response to low-dose hCG after GnRH antagonist administration. Follicle aspiration yielded one or more mature oocytes. In vitro fertilization and ET resulted in live births. Conclusion(s) Low-dose hCG can be used to complete follicle maturity in a natural cycle without the need for antecedent exogenous FSH stimulation. This finding may have strong clinical utility in modified natural cycle IVF. |
| Databáze: | OpenAIRE |
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