Mindfulness, Education, and Exercise for age-related cognitive decline: Study protocol, pilot study results, and description of the baseline sample
| Autor: | Susan R. Tate, Thomas L. Rodebaugh, Mary L. Uhrich, J. Philip Miller, Bruce W. Patterson, Eric J. Lenze, Erin R. Foster, Denise Head, Abraham Z. Snyder, Noralinda Kamantigue, Michelle L. Voegtle, Emily S. Bower, Gregory F. Wu, Hayley S Ripperger, Samuel Klein, Beau M. Ances, Colin A. Depp, Ginger E. Nicol, Joshua S. Shimony, David Wing, Tamara Hershey, Mary Stephens, Michael D. Yingling, David A. Balota, Steven D. Hickman, Julie Loebach Wetherell, Lisa T. Eyler, Jeanne F. Nichols |
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| Rok vydání: | 2020 |
| Předmět: |
Gerontology
Male Population ageing Mindfulness media_common.quotation_subject Sample (statistics) Pilot Projects Article 03 medical and health sciences 0302 clinical medicine Cognition Memory Aerobic exercise Medicine Humans Cognitive Dysfunction Meditation Cognitive decline Baseline (configuration management) Exercise Health Education media_common Aged Randomized Controlled Trials as Topic Pharmacology Protocol (science) business.industry 030229 sport sciences General Medicine Magnetic Resonance Imaging Treatment Outcome Cognitive Aging Female business 030217 neurology & neurosurgery |
| Zdroj: | Clin Trials |
| ISSN: | 1740-7753 |
| Popis: | Background/AimsAge-related cognitive decline is a pervasive problem in our aging population. To date, no pharmacological treatments to halt or reverse cognitive decline are available. Behavioral interventions, such as physical exercise and Mindfulness-Based Stress Reduction, may reduce or reverse cognitive decline, but rigorously designed randomized controlled trials are needed to test the efficacy of such interventions.MethodsHere, we describe the design of the Mindfulness, Education, and Exercise study, an 18-month randomized controlled trial that will assess the effect of two interventions—mindfulness training plus moderate-to-vigorous intensity exercise or moderate-to-vigorous intensity exercise alone—compared with a health education control group on cognitive function in older adults. An extensive battery of biobehavioral assessments will be used to understand the mechanisms of cognitive remediation, by using structural and resting state functional magnetic resonance imaging, insulin sensitivity, inflammation, and metabolic and behavioral assessments.ResultsWe provide the results from a preliminary study (n = 29) of non-randomized pilot participants who received both the exercise and Mindfulness-Based Stress Reduction interventions. We also provide details on the recruitment and baseline characteristics of the randomized controlled trial sample (n = 585).ConclusionWhen complete, the Mindfulness, Education, and Exercise study will inform the research community on the efficacy of these widely available interventions improve cognitive functioning in older adults. |
| Databáze: | OpenAIRE |
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