Enhanced levels of deoxycytidine kinase and thymidine kinase 1 and 2 after pulsed low dose rate irradiation as an adaptive response to radiation
| Autor: | Willem J.P Loves, Godefridus J. Peters, Chris van Bree, Natasja Castro Kreder, Jaap Haveman |
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| Přispěvatelé: | Center of Experimental and Molecular Medicine, Radiotherapy |
| Rok vydání: | 2002 |
| Předmět: |
Cancer Research
Lung Neoplasms Cell Survival Adaptation Biological General Medicine Deoxycytidine kinase Biology Cell cycle Radiation Dosage Thymidine Kinase Molecular biology Cytosol Oncology Epidermoid carcinoma Thymidine kinase Apoptosis Enzyme Induction Deoxycytidine Kinase Immunology Carcinoma Squamous Cell Tumor Cells Cultured Humans Cell survival curve Thymidine kinase 1 |
| Zdroj: | Oncology reports, 9(1), 141-144. Spandidos Publications Scopus-Elsevier |
| ISSN: | 1791-2431 1021-335X |
| DOI: | 10.3892/or.9.1.141 |
| Popis: | After pulsed low dose rate irradiation the activities of deoxycytidine kinase and thymidine kinase 1 and 2 were increased 1.5-2-fold 6 h after treatment. Twenty-four hours after treatment the activities of these enzymes had returned to control levels. We presume that the increase of enzyme activities is part of an adaptive response to irradiation and that this increase could be an explanation for the increased survival in the initial part of the SW-1573 cell survival curve. The observation that not only S-phase specific thymidine kinase 1 but also mitochondrial thymidine kinase 2 increases, implies that both these enzymes play a role in an adaptive response of cells to irradiation. |
| Databáze: | OpenAIRE |
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