Efficacy of n-3 fatty acids supplementation on the prevention of pregnancy induced-hypertension or preeclampsia: A systematic review and meta-analysis
| Autor: | Sepideh Mashayekh-Amiri, Sedigheh Esmailzadeh, Fatemeh Bakouei, Mouloud Agajani Delavar, Zeynab Taheri |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Cochrane Library lcsh:Gynecology and obstetrics Gastroenterology Preeclampsia 03 medical and health sciences 0302 clinical medicine Pre-Eclampsia Pregnancy Internal medicine Fatty Acids Omega-3 medicine Humans lcsh:RG1-991 chemistry.chemical_classification 030219 obstetrics & reproductive medicine business.industry Obstetrics and Gynecology Fatty acid Prenatal Care Hypertension Pregnancy-Induced Maternal Nutritional Physiological Phenomena medicine.disease Fish oil Eicosapentaenoic acid Treatment Outcome chemistry Docosahexaenoic acid Dietary Supplements Female business Polyunsaturated fatty acid |
| Zdroj: | Taiwanese Journal of Obstetrics & Gynecology, Vol 59, Iss 1, Pp 8-15 (2020) |
| ISSN: | 1028-4559 |
| DOI: | 10.1016/j.tjog.2019.11.002 |
| Popis: | The efficacy of n-3 fatty acids supplementation on the prevention of pregnancy-induced hypertension or preeclampsia remains unclear. The aim of study was to examine the effect of supplementation with EPA, and/or DHA, and/or ALA during pregnancy on the pregnancy-induced hypertension or preeclampsia. A systematic search was performed on Scopus, PubMed, Web of Science (WoS), Cochrane Library, and Google scholar, which covered the period between 1991 and 2018. The clinical trials with any control groups (i.e. placebo or other supplementation) were selected. The whole process of meta-analysis and data analysis was done using Comprehensive Meta-Analysis (Version 2.0, Biostat). The searched keywords were: “Fatty Acids, Omega-3”, “n-3 Polyunsaturated Fatty Acid” “Eicosapentaenoic Acid”, “Docosahexaenoic Acids”, “n-3 Polyunsaturated Fatty Acid”, “n-3 PUFAs”, “alpha-Linolenic Acid”, “fish oil”, “Nuts”, “nutrient”, or their synonyms “pregnancy induced hypertension” and preeclampsia. In addition, some key journals, according to Scopus report and the references of the original and review articles, were manually searched for possible related studies. The meta-analysis of the 14 comparisons demonstrated that n-3 fatty acids supplementation played a protective role against the risk of preeclampsia (RR, 0.82; 95% CI, 0.70–0.97; p = 0.024; I2 = 19.0%). The analysis of the 10 comparisons revealed that n-3 fatty acid supplements for pregnant women did not mitigate the risk of pregnancy-induced hypertension (RR, 0.98; 95% CI, 0.90–1.07; p = 0.652; I2 = 0%). The n-3 fatty acid supplements are an effective strategy to prevent the incidence of preeclampsia in women with low-risk pregnancies. Keywords: Omega-3, Pregnancy, Obstetrics, Pregnancy-induced hypertension, n-3 fatty acids |
| Databáze: | OpenAIRE |
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