Gene regulatory networks directing myeloid and lymphoid cell fates within the immune system
| Autor: | David W. Lancki, Jagan M. R. Pongubala, Harinder Singh, Peter Laslo |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Myeloid
Immunology Gene regulatory network Context (language use) Biology Cell fate determination Immune system medicine Animals Humans Immunology and Allergy Cell Lineage Gene Regulatory Networks Myeloid Cells Lymphocytes Lymphopoiesis Transcription factor Genetics Innate lymphoid cell Cell Differentiation Hematopoietic Stem Cells Hematopoiesis medicine.anatomical_structure Gene Expression Regulation Immune System Neuroscience |
| Zdroj: | Seminars in Immunology. 20:228-235 |
| ISSN: | 1044-5323 |
| Popis: | Considerable progress is being achieved in the analysis of gene regulatory networks that direct cell fate decisions within the hematopoietic system. In addition to transcription factors that are pivotal for cell fate specification and commitment, recent evidence suggests the involvement of microRNAs. In this review we attempt to integrate these two types of regulatory components into circuits that dictate cell fate choices leading to the generation of innate as well as adaptive immune cells. The developmental circuits are placed in the context of a revised scheme for hematopoiesis that suggests that both the innate (myeloid) and adaptive (lymphoid) lineages of the immune system arise from a common progenitor. |
| Databáze: | OpenAIRE |
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