Sensory nerves in the spotlight of the stem cell niche

Autor: Alexander Birbrair, Thiago M. Cunha, Rodrigo R. Resende, Pedro H.D.M. Prazeres, Beatriz G S Rocha, Anderson Oropeza, Pedro A C Costa, Vasco Azevedo, Akiva Mintz, Walison N. Silva, Gabryella S P Santos, Caroline C. Picoli, Rodrigo A. da Silva, Alinne C. Costa
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Stem Cells Translational Medicine
Stem Cells Translational Medicine, Vol 10, Iss 3, Pp 346-356 (2021)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
ISSN: 2157-6580
2157-6564
Popis: Niches are specialized tissue microenvironments that control stem cells functioning. The bone marrow mesenchymal stem cell niche defines a location within the marrow in which mesenchymal stem cells are retained and produce new cells throughout life. Deciphering the signaling mechanisms by which the niche regulates stem cell fate will facilitate the use of these cells for therapy. Recent studies, by using state‐of‐the‐art methodologies, including sophisticated in vivo inducible genetic techniques, such as lineage‐tracing Cre/loxP mediated systems, in combination with pharmacological inhibition, provide evidence that sensory neuron is an important component of the bone marrow mesenchymal stem cell niche. Strikingly, knockout of a specific receptor in sensory neurons blocked stem cell function in the bone marrow. The knowledge arising from these discoveries will be crucial for stem cell manipulation in the future. Here, we review recent progress in our understanding of sensory nerves biology in the stem cell niche.
Schematic illustration summarizing the findings from genetic deletion of EP4 specifically from sensory nerve fibers in the bone marrow mesenchymal stem cell niche.
Databáze: OpenAIRE
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