Immunogenicity and protection efficacy evaluation of avian paramyxovirus serotype-1 (APMV-1) isolates in experimentally infected chickens

Autor: Kizito K. Mugimba, Denis K. Byarugaba, Maxwell Otim-Onapa, Halid Kirunda, John Bosco Omony, Agnes Wanyana, Jessica L. Nakavuma
Rok vydání: 2017
Předmět:
Zdroj: Avian pathology : journal of the W.V.P.A. 46(4)
ISSN: 1465-3338
Popis: Vaccine failures after Newcastle disease vaccination with the current commercial vaccines have been reported and are associated with many factors, including genotypic and antigenic differences between vaccine and outbreak strains, although all APMV-1 members belong to one serotype. We assessed the immunoprotection ability of four thermostable, low-virulent Newcastle disease-virus isolates from Ugandan waterfowl against challenge with a virulent strain (MDT = 36.8 h, ICPI = 1.78) isolated from morbid chicken. Six-week-old commercial Leghorn layers, challenged at 21 days post immunization were used. Four isolates designated: NDV-133/UG/MU/2011, NDV-177/UG/MU/2011, NDV-178/UG/MU/2011 and NDV-173/UG/MU/2011 induced mean haemagglutinin inhibition antibody titres of log2 9.3, 8.2, 6.3 and 2.0, respectively, at 21 days post immunization. The antibody titres correlated with the protection rates (R² = 0.86, p
Databáze: OpenAIRE
Nepřihlášeným uživatelům se plný text nezobrazuje