Serum of Behqet's Disease Enhances Super oxide Production of Normal Neutrophils
| Autor: | Shunsaku Hirai, Makoto Tanaka, Koichi Okamoto, Akemi Sotomatsu, Toshihiko Yoshida |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male medicine.medical_specialty Neutrophils Priming (immunology) Stimulation Behcet's disease Biochemistry chemistry.chemical_compound Superoxides Internal medicine medicine Humans Opsonin business.industry Superoxide Behcet Syndrome Zymosan General Medicine Phorbol Myristate Acetate Middle Aged Opsonin Proteins medicine.disease N-Formylmethionine Leucyl-Phenylalanine Blood Endocrinology chemistry Luminescent Measurements Immunology Tetradecanoylphorbol Acetate Female business |
| Zdroj: | Free Radical Research. 28:39-44 |
| ISSN: | 1029-2470 1071-5762 |
| Popis: | Using an MCLA-dependent chemiluminescence technique, we evaluated superoxide production by neutrophils isolated from 7 patients with Behçet's disease. After stimulation by phorbol myristate acetate, N-formyl-methionyl-leucyl-phenylalanine or opsonized zymosan, neutrophils from the patients produced significantly more superoxide than those from 20 controls. Pretreatment of control neutrophils with serum prominently enhanced superoxide production, and serum from Behçet's disease patients had a significantly greater effect than that from controls. These findings suggest that serum from patients with Behçet disease contains the priming factor(s) that can enhance enhanced superoxide production by neutrophils in response to stimulation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|