The meaning of borderline rejection in kidney transplantation
| Autor: | Brian J. Nankivell |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Graft Rejection
0301 basic medicine Oncology medicine.medical_specialty Functional impairment Allograft failure T-Lymphocytes 030232 urology & nephrology Nephron law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine medicine Humans Transplantation Homologous Kidney transplantation Subclinical infection business.industry Banff schema medicine.disease Kidney Transplantation Tissue Donors 030104 developmental biology medicine.anatomical_structure Nephrology business Antibody formation |
| Zdroj: | Kidney International. 98:278-280 |
| ISSN: | 0085-2538 |
| DOI: | 10.1016/j.kint.2020.04.052 |
| Popis: | Borderline T cell-mediated rejection is a diagnostic category of the Banff schema that uses a lower diagnostic threshold. Subclinical borderline T cell-mediated rejection detected by surveillance sampling is not entirely benign. Studies demonstrate increased rates of late rejection, progressive nephron loss, functional impairment, donor-specific antibody formation, and allograft failure. It can be conceptualized as a failure to control the cellular alloimmune response. Mixed results are reported for its treatment, and randomized controlled trials are needed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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