Caffeine improves spatial learning deficits in an animal model of attention deficit hyperactivity disorder (ADHD) -- the spontaneously hypertensive rat (SHR)
| Autor: | Reinaldo N. Takahashi, Rui Daniel Prediger, Daniel Fernandes, Fabrício A. Pamplona |
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| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Morris water navigation task Blood Pressure Adenosinergic Impulsivity chemistry.chemical_compound Spontaneously hypertensive rat Memory Internal medicine Caffeine Rats Inbred SHR Genetic model medicine Attention deficit hyperactivity disorder Animals Pharmacology (medical) cardiovascular diseases Rats Wistar Maze Learning Pharmacology Dose-Response Relationship Drug medicine.disease Rats Psychiatry and Mental health Blood pressure Endocrinology chemistry Purinergic P1 Receptor Antagonists Attention Deficit Disorder with Hyperactivity Anesthesia cardiovascular system Central Nervous System Stimulants Female medicine.symptom Psychology |
| Zdroj: | The international journal of neuropsychopharmacology. 8(4) |
| ISSN: | 1461-1457 |
| Popis: | The spontaneously hypertensive rat (SHR) is generally considered to be a suitable genetic model for the study of attention deficit hyperactivity disorder (ADHD), since it displays hyperactivity, impulsivity, poorly sustained attention, and deficits in learning and memory processes. Converging evidence suggests a primary role of disturbance in the dopaminergic neurotransmission in ADHD patients and in SHR, and in addition, some studies have also demonstrated alterations in adenosinergic neurotransmission in SHR. In the present study, adult female Wistar (WIS) and SHR rats received caffeine (1-10 mg/kg i.p.) 30 min before training, immediately after training, or 30 min before a test session in the spatial version of the Morris water maze. The effect of caffeine administration on WIS and SHR blood pressure was also measured. SHR needed significantly more trials in the training session to acquire the spatial information, but they displayed a similar profile to that of WIS rats in the test session (48 h later), demonstrating a selective deficit in spatial learning. Pre-training administration of caffeine (1-10 mg/kg i.p.) improved this spatial learning deficit in SHR, but did not alter the WIS performance. In contrast, post-training administration of caffeine (3 mg/kg i.p.) did not alter the SHR test performance, but increased memory retention in WIS rats. No dose of caffeine tested altered the mean blood pressure of WIS or SHR. These results demonstrate a selective spatial learning deficit in SHR which can be attenuated by pre-training administration of caffeine. In addition, the present findings indicate that the spatial learning deficit in SHR is not directly related to hypertension. |
| Databáze: | OpenAIRE |
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