Subtherapeutic Photodynamic Treatment Facilitates Tumor Nanomedicine Delivery and Overcomes Desmoplasia
| Autor: | Maneesha A Rajora, Marta Overchuk, Danielle M. Charron, Brian C. Wilson, Shrey Sindhwani, Warren C. W. Chan, Gang Zheng, Martin G. Pomper, Abdullah Muhammad Syed, Adam Koebel, Juan Chen, Kara M. Harmatys |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Programmed cell death medicine.medical_treatment Priming (immunology) Bioengineering Photodynamic therapy Antineoplastic Agents 02 engineering and technology Extracellular matrix Prostate cancer Mice Neoplasms medicine Animals General Materials Science business.industry Mechanical Engineering General Chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics medicine.disease 3. Good health Desmoplasia Nanomedicine Photochemotherapy Toxicity Cancer research Nanoparticles medicine.symptom 0210 nano-technology business |
| Zdroj: | Nano letters. 21(1) |
| ISSN: | 1530-6992 |
| Popis: | Limited tumor nanoparticle accumulation remains one of the main challenges in cancer nanomedicine. Here, we demonstrate that subtherapeutic photodynamic priming (PDP) enhances the accumulation of nanoparticles in subcutaneous murine prostate tumors ∼3-5-times without inducing cell death, vascular destruction, or tumor growth delay. We also found that PDP resulted in an ∼2-times decrease in tumor collagen content as well as a significant reduction of extracellular matrix density in the subendothelial zone. Enhanced nanoparticle accumulation combined with the reduced extravascular barriers improved therapeutic efficacy in the absence of off-target toxicity, wherein 5 mg/kg of Doxil with PDP was equally effective in delaying tumor growth as 15 mg/kg of Doxil. Overall, this study demonstrates the potential of PDP to enhance tumor nanomedicine accumulation and alleviate tumor desmoplasia without causing cell death or vascular destruction, highlighting the utility of PDP as a minimally invasive priming strategy that can improve therapeutic outcomes in desmoplastic tumors. |
| Databáze: | OpenAIRE |
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