Intermediate Filaments of the Vimentin and Prekeratin Type in Human Epidermis
| Autor: | Klaus Weber, G. Mahrle, Regine Bolling, Mary Osborn |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Pathology
medicine.medical_specialty Fluorescent Antibody Technique Vimentin Human skin macromolecular substances Dermatology Biochemistry 030207 dermatology & venereal diseases 03 medical and health sciences Basal (phylogenetics) 0302 clinical medicine Intermediate Filament Proteins medicine Humans Protein Precursors Intermediate filament Molecular Biology Cytoskeleton 030304 developmental biology 0303 health sciences Frozen section procedure biology Epidermis (botany) Histocytochemistry Cell Biology 3. Good health Cell biology Epidermal Cells biology.protein Keratins Epidermis Antibody Intracellular |
| Zdroj: | Journal of Investigative Dermatology. (1):46-48 |
| ISSN: | 0022-202X |
| DOI: | 10.1111/1523-1747.ep12538403 |
| Popis: | Monospecific antibodies to intermediate filaments of mesenchymally derived vimentin, applied to frozen sections of human skin, specifically stained dendritic basal and suprabasal cells. Cellular morphology, distribution, reaction pattern with anti-HLA-DR in serial sections, and OKT6 in double-staining procedures identified these cells as melanocytes and Langerhans cells. As shown previously in animals keratinocytes stained with anti-prekeratin exclusively. Thus, vimentin is an intracellular marker for Langerhans cells and melanocytes, differentiating them from keratinocytes. |
| Databáze: | OpenAIRE |
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