Electronic effects in 1,3-dipolar cycloaddition reactions of N-alkyl and N-benzyl nitrones with dipolarophiles

Autor:	Andrei Badoiu, E. Peter Kündig
Jazyk:	angličtina
Rok vydání:	2012
Předmět:	chemistry.chemical_classification Organic Chemistry chemistry.chemical_element Biochemistry Medicinal chemistry Ruthenium Lewis acid catalysis chemistry 1 3-Dipolar cycloaddition ddc:540 Electronic effect Organic chemistry Physical and Theoretical Chemistry Alkyl Electronic properties
Zdroj:	Organic and Biomolecular Chemistry, Vol. 10, No 1 (2012) P. 114
ISSN:	1477-0520
Popis:	1,3-Dipolar cycloadditions afforded fast access to isoxazolidines bearing N-alkyl or N-benzyl substituents. The electronic properties of the substituents in the nitrones define the activity of the dipoles and modulate diastereoselectivity in the non-catalyzed reactions. Using a chiral one-point binding ruthenium Lewis acid catalyst, products were obtained in good yields and with excellent regio-, diastereo-, and enantioselectivity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69b9b2ba2006ceccdf18df0fb8b795ea https://archive-ouverte.unige.ch/unige:17734 Zobrazit plný text záznamu