Type I IFN family members: Similarity, differences and interaction

Autor: Elena Uleri, Antonina Dolei, Claudia Caglioti, Maria Rosaria Capobianchi
Jazyk: angličtina
Rok vydání: 2014
Předmět:
ds
double strand

GAS
gamma interferon activation site

MSMD
Mendelian susceptibility to mycobacterial disease

PD-L1
programmed death ligand 1

Endocrinology
Diabetes and Metabolism

ISGF3
interferon-stimulated gene factor 3

Anti-interferon strategies
IFI16
gamma-interferon-inducible protein 16

TYK2
tyrosine kinase 2

Receptor
Interferon alpha-beta

AP-1
activator protein 1

APCs
antigen presenting cells

TREX1
three prime repair exonuclease 1

CRF2
class II cytokine receptor family

hCMV
human Cytomegalovirus

Immunology and Allergy
CHIKV
Chickungunya virus

SARS-CoV
severe acute respiratory syndrome-associated coronavirus

SOCS
suppressor of cytokine signaling

Toll-like receptor
education.field_of_study
Effector
NF-κB
nuclear factor kappa-light-chain-enhancer of activated B cells

Pattern recognition receptor
MDA5
PRRs
pattern-recognition receptors

Cell Differentiation
Acquired immune system
Th
lymphocytes T helper

ISRE
interferon stimulated response element

WNV
West Nile virus

IRAK-4
interleukin-1 receptor-associated kinase 4

Virus Diseases
HCV
hepatitis C virus

IFNGR
interferon gamma receptor

SNPs
single nucleotide polymorphisms

Interferon Type I
Interferon genes and receptors
IPS-1
interferon promoter-stimulating factor 1

JAK
Janus kinase

TLR
Toll-like receptor

Signal Transduction
Transcriptional Activation
HSV-1
herpes simplex virus-1

VSV
vesicular stomatitis virus

ATF6
activating transcription factor 6

Immunology
VZV
Varicella-Zoster virus

Three prime repair exonuclease 1
Biology
NEMO
nuclear factor (NF)-kB essential modulator

Antiviral Agents
General Biochemistry
Genetics and Molecular Biology

Article
NK
natural killer cells

Interferon–interferon interactions
MS
multiple sclerosis

Interferon-gamma
STAT
Signal Transducer and Activator of Transcription

EM
environmental mycobacteria

HSE
herpes simplex encephalitis

MHC
major histocompatibility complex

Humans
IFN
interferon

SAMHD1
SAM domain and HD domain-containing protein 1

SARS
severe acute respiratory syndrome

education
LASV
Lassa virus

Cell Proliferation
ADAR1
adenosine deaminase acting on RNA 1

Cyclic GMP-AMP synthase
IFNAR
interferon alpha receptor

Interferon types I–III
Genetic Variation
EMCV
encephalomyocarditis virus

EAE
experimental allergic encephalomyelitis

MxA
Myxovirus Resistance Gene A

IL
interleukin

MDA5
melanoma differentiation-associated protein 5

OAS
2′
5′-oligo adenylate synthetase A

p300/CBP
chromatin remodeling associated p300/CREB-binding protein

PKR
dsRNA-dependent protein kinase

ss
single strand

cGAS
cyclic GMP-AMP synthase

MAPK
mitogen-activated protein kinases

BCG
bacille Calmette–Guérin

STAT protein
Interferons
RIG-1
retinoic-acid-inducible gene 1

IRF
interferon regulatory factor
Zdroj: Cytokine & Growth Factor Reviews
ISSN: 1879-0305
1359-6101
Popis: Interferons (IFN) are key cytokines with multifaceted antiviral and cell-modulatory properties. Three distinct types of IFN are recognized (I-III) based on structural features, receptor usage, cellular source and biological activities. The action of IFNs is mediated by a complex, partially overlapping, transcriptional program initiated by the interaction with specific receptors. Genetic diversity, with polymorphisms and mutations, can modulate the extent of IFN responses and the susceptibility to infections. Almost all viruses developed mechanisms to subvert the IFN response, involving both IFN induction and effector mechanisms. Interactions between IFN types may occur, for both antiviral and cell-modulatory effects, in a complex interplay, involving both synergistic and antagonistic effects. Interferon-associated diseases, not related to virus infections may occur, some of them frequently observed in IFN-treated patients. On the whole, IFNs are pleiotropic biologic response modifiers, that, upon activation of thousands genes, induce a broad spectrum of activities, regulating cell cycle, differentiation, plasma membrane molecules, release of mediators, etc., that can be relevant for cell proliferation, innate and adaptive immunity, hematopoiesis, angiogenesis and other body functions.
Databáze: OpenAIRE