Experimental mandibular regrowth by distraction osteogenesis. Long-term results
| Autor: | Glenn Houston, Peter D. Costantino, Craig D. Friedman, George A. Sisson, Maise L. Shindo |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Bone Regeneration Time Factors Medullary cavity External Fixators medicine.medical_treatment Stress testing Dentistry Mandible Bone Nails Osteotomy Calcification Physiologic Dogs Bone Lengthening Osteogenesis Distraction Periosteum medicine Animals Craniofacial Bony Callus Wound Healing business.industry General Medicine medicine.disease Biomechanical Phenomena Haversian System Radiography Otorhinolaryngology Orthopedic surgery Distraction osteogenesis Surgery Stress Mechanical business Calcification |
| Zdroj: | Archives of otolaryngology--headneck surgery. 119(5) |
| ISSN: | 0886-4470 |
| Popis: | • The use of gradual distraction to grow bone (distraction osteogenesis) has gained widespread orthopedic acceptance, but has only recently been applied to craniofacial skeletal defects. The use of bifocal distraction osteogenesis to fill experimental segmental mandibular defects with regenerate bone was recently reported. Though all canines in that study demonstrated normal oromandibular function, they were observed for only 4 weeks following defect closure. The study that is now reported describes the long-term (12-month) functional, morphologic, and biomechanical results when bifocal distraction osteogenesis was applied to the same model. In this long-term study, three canines had 2.5-cm unilateral segmental mandibular body defects filled with structurally stable bone using bifocal distraction osteogenesis. These dogs exhibited normal oromandibular function for 1 year following segment regrowth and external fixator removal. Macroscopic and histologic evaluation of the regrown segments revealed a re-formation of the cortical and medullary architecture. Stress testing demonstrated the average ultimate strength of the regrown segment at 53 MPa, which corresponded to 77%±5.7% of normal mandibular bone. The data suggest that clinical trials applying this technique to segmental mandibular reconstruction are warranted. ( Arch Otolaryngol Head Neck Surg. 1993;119:511-516) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|