Renal Developmental Arrest in Sudden Infant Death Syndrome
| Autor: | Brian A. Judd, C. Vyvyan Howard, S. A. Hinchliffe, Dick van Velzen, Paul H. Sargent, Matthew R. J. Lynch |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Developmental defect Birth weight Qualitative evidence Physiology Developmental arrest Normal values Nephron Pathology and Forensic Medicine Risk Factors medicine Birth Weight Humans Fetal Growth Retardation business.industry Infant Human kidney Nephrons Sudden infant death syndrome medicine.anatomical_structure Pediatrics Perinatology and Child Health Female business Sudden Infant Death |
| Zdroj: | Pediatric Pathology. 13:333-343 |
| ISSN: | 0277-0938 |
| DOI: | 10.3109/15513819309048221 |
| Popis: | Investigations linking sudden infant death syndrome (SIDS) and type II intrauterine growth retardation (IUGR) have thus far failed due in part to technical limitations. Recently developed stereological methods for the unbiased estimation of total nephron number in the human kidney are capable of detecting deviations from normal values of greater than 10%. We compared the total number of nephrons in the kidneys of 24 SIDS victims with those from 16 controls with the same age range. Mean nephron number was significantly (P < 0.001) reduced in ex-IUGR SIDS cases (birthweight under the 10th centile, n = 9, mean number 635,000, range 327,000-1,010,000) in comparison with controls (903,000, 740,000-1,060,000). A similarly significant (P < 0.01) reduction in the "normal birthweight" SIDS group (birthweight over 10th centile, n = 15, 690,000, 361,000-1,040,000) was found. This hitherto unreported renal developmental arrest may be only one manifestation of a general, somatic developmental defect, reflecting adverse intrauterine conditions; other organ systems, similarly critical to homeostasis may be comparably affected. The findings, although not proposed as direct cause of SIDS, may represent a potential explanation for the recognized association of IUGR and SIDS, and provide--we believe--the first quantitative evidence of intrauterine growth retardation in, at least a number of, children of average birthweight. |
| Databáze: | OpenAIRE |
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