Isokibdelones: Novel Heterocyclic Polyketides from a Kibdelosporangium sp

Autor:	Ranjala Ratnayake, Robert J. Capon, Shaun Tennant, Jennifer H. Gill, Ernest Lacey
Rok vydání:	2006
Předmět:	Molecular Structure Stereochemistry Chemistry Organic Chemistry Kibdelosporangium sp Antineoplastic Agents General Medicine Biochemistry Combinatorial chemistry Anti-Bacterial Agents Actinomycetales Macrolides Physical and Theoretical Chemistry Pharmacophore
Zdroj:	Organic Letters. 8:5267-5270
ISSN:	1523-7052 1523-7060
DOI:	10.1021/ol062113e
Popis:	[Structure: see text] The isokibdelones are an unprecedented family of polyketides produced by an Australian isolate of a rare actinomycete, Kibdelosporangium sp. The structures of the isokibdelones were assigned by spectroscopic analysis and chemical interconversion. A proposed biosynthesis requires a novel molecular twist that generates an unprecedented heterocyclic system and differentiates the isokibdelones from their kibdelone co-metabolites. SAR analysis on the isokibdelones further defines the anticancer pharmacophore of these novel polyketides.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69b039fe26a271df40922406ecdc0397 https://doi.org/10.1021/ol062113e Zobrazit plný text záznamu