Chromosome-Wide Impacts on the Expression of Incompatibilities in Hybrids of Tigriopus californicus
| Autor: | Lydia Hatfield, Thiago G. Lima, Christopher S. Willett, Inna Kovaleva |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Mitochondrial DNA Genotype copepod Gene Expression Investigations QH426-470 Genome Polymorphism Single Nucleotide Chromosomes Copepoda 03 medical and health sciences symbols.namesake Genetics Tigriopus californicus Animals Allele Molecular Biology Genetics (clinical) Crosses Genetic Dobzhansky-Muller incompatibilities biology Reproduction Chromosome Epistasis Genetic Reproductive isolation biology.organism_classification 030104 developmental biology Genetics Population Mendelian inheritance symbols Hybridization Genetic Female Mendelian ratio deviations postzygotic reproductive isolation |
| Zdroj: | G3: Genes, Genomes, Genetics, Vol 6, Iss 6, Pp 1739-1749 (2016) G3: Genes|Genomes|Genetics |
| ISSN: | 2160-1836 |
| DOI: | 10.1534/g3.116.028050 |
| Popis: | Chromosome rearrangements such as inversions have been recognized previously as contributing to reproductive isolation by maintaining alleles together that jointly contribute to deleterious genetic interactions and postzygotic reproductive isolation. In this study, an impact of potential incompatibilities merely residing on the same chromosome was found in crosses of populations of the copepod Tigriopus californicus. When genetically divergent populations of this copepod are crossed, hybrids show reduced fitness, and deviations from expected genotypic ratios can be used to determine regions of the genome involved in deleterious interactions. In this study, a set of markers was genotyped for a cross of two populations of T. californicus, and these markers show widespread deviations from Mendelian expectations, with entire chromosomes showing marked skew. Despite the importance of mtDNA/nuclear interactions in incompatibilities in this system in previous studies, in these crosses the expected patterns stemming from these interactions are not widely apparent. Females lack recombination in this species, and a striking difference is observed between male and female backcrosses. This suggests that the maintenance of multiple loci on individual chromosomes can enable some incompatibilities, perhaps playing a similar role in the initial rounds of hybridization to chromosomal rearrangements in preserving sets of alleles together that contribute to incompatibilities. Finally, it was observed that candidate pairs of incompatibility regions are not consistently interacting across replicates or subsets of these crosses, despite the repeatability of the deviations at many of the single loci themselves, suggesting that more complicated models of Dobzhansky-Muller incompatibilities may need to be considered. |
| Databáze: | OpenAIRE |
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