Anthropometry, carbohydrate and lipid metabolism in the East Flanders Prospective Twin Survey: linkage of candidate genes using two sib-pair based variance components analyses
| Autor: | N Y Souren, Alphons P. M. Stassen, Robert Vlietinck, Ruth J. F. Loos, Anja Steyls, Aimee D C Paulussen, Rob G J H Janssen, Jeroen Aerssens, Catherine Derom, Marij Gielen, Maurice P. Zeegers, Gaston Beunen, Robert Fagard |
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| Přispěvatelé: | Populatie Genetica, RS: NUTRIM - R4 - Gene-environment interaction, RS: NUTRIM - R1 - Metabolic Syndrome |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Candidate gene Genotype Genetic Linkage Birth weight Type 2 diabetes Biology Insulin resistance Belgium Genetic linkage medicine Twins Dizygotic Humans Prospective Studies Genetics (clinical) Genetics Anthropometry Obstetrics and Gynecology Twins Monozygotic medicine.disease Lipid Metabolism Twin study Diabetes Mellitus Type 2 Pediatrics Perinatology and Child Health Microsatellite Carbohydrate Metabolism Female Microsatellite Repeats |
| Zdroj: | Twin Research and Human Genetics, 11(5), 505-16. Australian Academic Press |
| ISSN: | 1832-4274 |
| DOI: | 10.1375/twin.11.5.505 |
| Popis: | Insulin resistance and obesity are underlying causes of type 2 diabetes and therefore much interest is focused on the potential genes involved. A series of anthropometric and metabolic characteristic were measured in 240 MZ and 112 DZ twin pairs recruited from the East Flanders Prospective Twin Survey. Microsatellite markers located close to ABCC8, ADIPOQ, GCK, IGF1, IGFBP1, INSR, LEP, LEPR, PPARγ and the RETN gene were genotyped. Univariate single point variance components linkage analyses were performed using two methods: (1) the standard method, only comprising the phenotypic and genotypic data of the DZ twin pairs and (2) the extended method, also incorporating the phenotypic data of the MZ twin pairs. Suggestive linkages (LOD > 1) were observed between the ABCC8 marker and waist-to-hip ratio and HDL-cholesterol levels. Both markers flanking ADIPOQ showed suggestive linkage with triglycerides levels, the upstream marker also with body mass and HDL-cholesterol levels. The IGFBP1 marker showed suggestive linkage with fat mass, fasting insulin and leptin levels and the LEP marker showed suggestive linkage with birth weight. This study suggests that DNA variants in ABCC8, ADIPOQ, IGFBP1 and LEP gene region may predispose to type 2 diabetes. In addition, the two methods used to perform linkage analyses yielded similar results. This was however not the case for birth weight where chorionicity seems to be an important confounder. |
| Databáze: | OpenAIRE |
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