Spirulina platensis alleviates high fat diet-induced cognitive impairment in mice via the gut-brain axis
| Autor: | Tian Xue, Qiulian Wang, Yan Liu, Lingzheng Meng, Yinping Pan, Qingquan Dou, Tao Zhou, Xukai Li |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Gut–brain axis Spirulina platensis Medicine (miscellaneous) Morris water navigation task Gut microbiota Biology Neuroinflammation Internal medicine medicine Hippocampus (mythology) TX341-641 Cognitive impairment Spirulina (genus) Nutrition and Dietetics Nutrition. Foods and food supply digestive oral and skin physiology High fat diet biology.organism_classification Barnes maze Tau-hyperphosphorylation Endocrinology Aβ production Alzheimer’s disease Food Science |
| Zdroj: | Journal of Functional Foods, Vol 86, Iss, Pp 104706-(2021) |
| ISSN: | 1756-4646 |
| DOI: | 10.1016/j.jff.2021.104706 |
| Popis: | Increasing evidence suggested that the gut microbiome-brain axis plays a critical role in regulating cognitive functions. In this study, we aimed to investigate the dietary treatment effect of Spirulina platensis on learning deficits in high fat diet (HFD) fed mice and clarify the potential mechanisms via investigating the gut microbiome-brain axis. Dietary administration of 1% and 2% Spirulina platensis for 16 weeks significantly improved the spatial learning and memory performance of the HFD-fed mice in both Barnes Maze test and Morris water maze test. The Aβ accumulation, tau-hyperphosphorylation, and neuroinflammation in the hippocampus were significantly inhibited by Spirulina platensis. Spirulina platensis also abrogated HFD induced gut microbial dysbiosis and unbalance of gut microbial metabolites indicating its modulating effect on the gut-brain axis. This study provides further evidence for the application of Spirulina platensis as functional supplement for treatment of Alzheimer’s disease. |
| Databáze: | OpenAIRE |
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