Heritability of Testis Size
| Autor: | Henriette A. Delemarre-van de Waal, Dorret I. Boomsma, Meike Bartels, G. Frederiek Estourgie-van Burk |
|---|---|
| Přispěvatelé: | Pediatric surgery, EMGO - Mental health, Biological Psychology, EMGO+ - Mental Health |
| Rok vydání: | 2009 |
| Předmět: |
Male
Netherlands Twin Register (NTR) Adolescent Shared environment Dizygotic twin Twins Monozygotic twin Environment Biology Dizygotic twins 03 medical and health sciences 0302 clinical medicine Testis Twins Dizygotic Humans Genetic Predisposition to Disease Longitudinal Studies Sibling Genetics (clinical) 030304 developmental biology 0303 health sciences 030219 obstetrics & reproductive medicine Siblings Obstetrics and Gynecology Organ Size Twins Monozygotic Heritability Twin study Phenotype Pediatrics Perinatology and Child Health Human testis Demography |
| Zdroj: | Twin Research and Human Genetics, 12(4), 351-355. Cambridge University Press ResearcherID Estourgie-van Burk, G F, Bartels, M, Delemarre-van de Waal, H A & Boomsma, D I 2009, ' Heritability of Testis Size ', Twin Research and Human Genetics, vol. 12, no. 4, pp. 351-355 . https://doi.org/10.1375/twin.12.4.351 Twin Research and Human Genetics, 12(4), 351-355. Australian Academic Press |
| ISSN: | 1839-2628 1832-4274 |
| DOI: | 10.1375/twin.12.4.351 |
| Popis: | Testis size is an important feature of male pubertal development. The genetic and environmental contributions to variation in human testis size have hardly been studied. We estimated the heritability of human testicular size in a group of mono- and dizygotic twins and their non-twin brothers (145 twins and 20 brothers from 95 families). Participants were 18 years old on average and all had reached Tanner development stage 4 or higher. Dizygotic twins and their siblings had a larger mean testis volume than monozygotic twins and their siblings. There was significant familial resemblance, with higher correlations in monozygotic twin pairs (0.59) than in dizygotic twin and sibling pairs (0.34). Heritability was estimated at 59% (95% CI = 37–75%), but a model that excluded genetic influences and attributed all familial resemblance to shared environment, fitted the data only marginally worse. The finding of larger mean testis volume in dizygotic twins may be of interest for future research into the mechanisms underlying dizygotic twinning. |
| Databáze: | OpenAIRE |
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