sRAGE and early signs of cardiac target organ damage in mild hypertensives

Autor: Andrea Maria Maresca, Rossana Corso, Francesco G. Zerba, C. Mongiardi, N. Tandurella, Francesco Dentali, Anna Maria Grandi, Leonardo Campiotti, Alessandro Squizzato, Colomba Falcone, Sara Bozzini, Catherine Klersy, Luigina Guasti
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
lcsh:Diseases of the circulatory (Cardiovascular) system
Endocrinology
Diabetes and Metabolism
Receptor for Advanced Glycation End Products
Blood Pressure
030204 cardiovascular system & hematology
Left ventricular hypertrophy
Severity of Illness Index
Ventricular Function
Left
0302 clinical medicine
Risk Factors
Cardiac target organ damage
Original Investigation
Body surface area
education.field_of_study
Ventricular Remodeling
Mild hypertension
Blood Pressure Monitoring
Ambulatory
Middle Aged
Echocardiography
Doppler
Hypertension
Disease Progression
Cardiology
Female
Hypertrophy
Left Ventricular
Cardiology and Cardiovascular Medicine
sRAGE
Adult
medicine.medical_specialty
Ambulatory blood pressure
Population
Inflammation
Left atrial volume index
Left ventricular mass index
Oxidative stress
Down-Regulation
030209 endocrinology & metabolism
03 medical and health sciences
Predictive Value of Tests
Diabetes mellitus
Internal medicine
medicine
Humans
education
Angiology
business.industry
medicine.disease
Early Diagnosis
Blood pressure
lcsh:RC666-701
Case-Control Studies
business
Body mass index
Biomarkers
Zdroj: Cardiovascular Diabetology, Vol 18, Iss 1, Pp 1-8 (2019)
Cardiovascular Diabetology
ISSN: 1475-2840
Popis: Background Soluble Receptor for Advanced Glycation End Products (sRAGE) may be considered a marker inversely related to inflammation and its participation has been established in patients with advanced atherosclerotic vascular diseases. However, it is still unknown whether sRAGE reduction could be early metabolic change in the first stage of hypertension and initial hypertension-associated cardiac damage. We sought to determine the sRAGE values in otherwise healthy, untreated and recently diagnosed mild hypertensives and evaluate their association with blood pressure (BP) values, metabolic parameters, and with subclinical initial signs of cardiac target organ damage (TOD). Methods sRAGE were measured in 100 hypertensive and 100 normotensive subjects matched for age, gender and body mass index (BMI), submitted to a clinic visit and both ambulatory BP monitoring and echocardiography to determine the presence of initial cardiac TOD (presence of signs of left ventricular hypertrophy: left ventricular mass indexed for height2.7 (LVMi) > 48 g/m2.7 for men and > 44 g/m2.7 for women and/or increased left atrial volume 4-chamber indexed for body surface area (LAVi) > 34 ml/m2). Results sRAGE levels were similar between hypertensive and normotensive subjects and were not significantly correlated with office and 24-h BPs values. However, when subgrouping the hypertensive patients in Hyp-TOD and Hyp-withoutTOD, sRAGE was found to be different among the three groups (p = 0.030), being lower in the Hyp-TOD group than the values of both Hyp-withoutTOD (p = 0.038) and normotensives (p = 0.038). In hypertensive patients sRAGE was negatively related with both LVMi (r = − 0.239, p = 0.034) and LAVi (r = − 0.315, p = 0.005) and was independently related to cardiac TOD also in multivariable analysis. Conclusions In this population of mild hypertensives, low circulating sRAGE may be a very early marker of initial TOD, suggesting the possible participation of oxidative stress in initial cardiac changes in human hypertension. Electronic supplementary material The online version of this article (10.1186/s12933-019-0821-5) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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