Haemolytic anaemia after childhoodEscherichia coliO 157.H7 infection: are females at increased risk?
| Autor: | Peter C. Rowe, A. M. Mackenzie, H. Lior, W. Walop |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Serotype Hemolytic anemia Anemia Hemolytic medicine.medical_specialty Adolescent Epidemiology Anemia Bacterial Toxins Biology Shiga Toxin 1 Polymerase Chain Reaction Gastroenterology Cohort Studies Enterotoxins Feces Hemoglobins Sex Factors Risk Factors hemic and lymphatic diseases Internal medicine Escherichia coli medicine Humans Child Escherichia coli Infections Retrospective Studies Age Factors Infant Retrospective cohort study Odds ratio medicine.disease Gastroenteritis Infectious Diseases Child Preschool Hemolytic-Uremic Syndrome Cohort Immunology Female Seasons Research Article Cohort study |
| Zdroj: | Epidemiology and Infection. 106:523-530 |
| ISSN: | 1469-4409 0950-2688 |
| DOI: | 10.1017/s0950268800067583 |
| Popis: | SUMMARYWe conducted a 4-year retrospective cohort study to better define the risk of haemolytic anaemia and haemolytic uraemic syndrome (HUS) in children following sporadic gastrointestinal infection with the O 157.H7 serotype ofEscherichia coli. Of the 72 children infected with this organism, 9 (12·5%) developed haemolytic anaemia, 6 of whom had HUS. No child in a cohort of 72 age-matched controls withCampylobacter jejunigastroenteritis developed haemolytic anaemia (P= 0·003). Females had a significantly greater risk of developing haemolytic anaemia afterE. coliO 157.H7 infection than did males (8/29 femalesv.1/43 males;P= 0·003). In a logistic regression model, female gender emerged as the only statistically significant risk factor for haemolytic anaemia (odds ratio 3·85; 95% confidence interval 1·24–12). These results are consistent with recent reports of a moderate increase in the risk of HUS for females. |
| Databáze: | OpenAIRE |
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