The role of Homeobox genes in normal hematopiesis and hematological malignancies
| Autor: | J. W. Van Oostveen, J. J. M. Walboomers, F. M. Raaphorst, J. J. Bijl, C. J. L. M. Meijer |
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| Přispěvatelé: | VU University medical center |
| Jazyk: | angličtina |
| Rok vydání: | 1999 |
| Předmět: |
Cancer Research
animal structures Biology Blood cell Pathogenesis Embryonic and Fetal Development medicine Humans Cell Lineage Hox gene Gene Genetics Leukemia Lymphoma Non-Hodgkin Genes Homeobox Hematology medicine.disease Hematopoiesis Cell biology Haematopoiesis medicine.anatomical_structure Oncology Hematologic Neoplasms embryonic structures Homeobox Homeotic gene Cell Adhesion Molecules Transcription Factors |
| Zdroj: | Leukemia, 13, 1675-1690. Nature Publishing Group van Oostveen, J W, Bijl, J J, Raaphorst, F M, Walboomers, J M M & Meijer, C J L M 1999, ' The role of Homeobox genes in normal hematopiesis and hematological malignancies ', Leukemia, vol. 13, pp. 1675-1690 . https://doi.org/10.1038/sj.leu.2401562 |
| ISSN: | 0887-6924 |
| DOI: | 10.1038/sj.leu.2401562 |
| Popis: | In the last decade it has become clear that homeobox containing genes (HOX genes) not only play a significant role in regulating body formation, but in addition, they are contributing to organization and regulation of hematopoiesis. Modern molecular technologies showed that deregulated expression or disruption of Hox genes can lead to altered characteristics of blood cells or disturbance of blood cell development. In this paper we review the role of HOX proteins in hematopoiesis and leukemogenesis and speculate about their possible target genes and involvement in lymphomagenesis. |
| Databáze: | OpenAIRE |
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