Recent Progress in Studies of Pituitary Tumor Pathogenesis
Autor: | Susumu Takekoshi, Masanori Suzuki, Shunsuke Miyai, Naoko Sanno, Akira Teramoto, Hanako Kajiya, Robert Yoshiyuki Osamura, Takeo Minematsu |
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Rok vydání: | 2005 |
Předmět: |
Adenoma
medicine.medical_specialty medicine.drug_class Endocrinology Diabetes and Metabolism Cellular differentiation Estrogen receptor Cell Cycle Proteins Biology medicine.disease_cause Mice Endocrinology Cyclin-dependent kinase Internal medicine medicine Animals Humans Pituitary Neoplasms Transcription factor Pituitary tumors Cell cycle medicine.disease Gene Expression Regulation Neoplastic Estrogen biology.protein Cancer research Carcinogenesis Transcription Factors |
Zdroj: | Scopus-Elsevier |
ISSN: | 0969-711X |
Popis: | The mechanisms of tumorigenesis of the human pituitary have been elucidated to a limited extent. Classically, pituitary tumor formation was shown to be induced by thyroidectomy and estrogen administration. Molecular biological and immunohistochemical studies have revealed several aspects of pituitary tumorigenesis. Translineage cell differentiation has been shown to be induced by the aberrant expression of transcription factors and co-factors, such as Pit-1, Prop-1, and estrogen receptor. Defects or overexpression of cell cycle regulators, such as CDK inhibitors, PTTG, and GADD45gamma, result in the abnormal proliferation of pituitary cells. Recently, epigenetic regulation has been suggested to be related to pituitary tumor formation. This article presents a review and update of recent progress in studies of the development and differentiation of pituitary tumors. |
Databáze: | OpenAIRE |
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