Copper-catalyzed cycloisomerization of alkynylaziridines to access functionalized 2-substituted-4-formylpyrroles

Autor:	Phannarath Phansavath, Virginie Ratovelomanana-Vidal, Gérard Guillamot, Anne Westermeyer
Přispěvatelé:	Institute of Chemistry for Life and Health Sciences (iCLeHS), Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	010405 organic chemistry Chemistry Aryl Organic Chemistry Regioselectivity 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound Cycloisomerization Drug Discovery Copper catalyzed [CHIM]Chemical Sciences
Zdroj:	Tetrahedron Tetrahedron, Elsevier, 2020, 76, pp.131221-. ⟨10.1016/j.tet.2020.131221⟩
ISSN:	0040-4020
Popis:	The copper-catalyzed cycloisomerization of alkynylaziridines has been developed to access 2-substituted-4-formylpyrroles. The reaction proved to be tolerant to aryl and alkyl-substituted substrates which were readily prepared from the corresponding enynes. This atom-economical catalytic process gives a convenient and regioselective access to a wide range of diversely 2-substituted-4-formylpyrroles in a two-step procedure.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a2762aa7a16921124707722f09bea7 https://hal.archives-ouvertes.fr/hal-03493777 Zobrazit plný text záznamu Full Text from ScienceDirect