Épigénome et syndrome de Gougerot-Sjögren
| Autor: | Amandine Charras, Anne Bordron, Yves Renaudineau, C. Le Dantec |
|---|---|
| Přispěvatelé: | LabEX IGO Immunothérapie Grand Ouest, Lymphocyte B et Auto-immunité (LBAI), Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire d'Immunologie et Immunothérapie [Brest], Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO) |
| Rok vydání: | 2018 |
| Předmět: |
030203 arthritis & rheumatology
0301 basic medicine Autoimmune disease Chemokine biology business.industry [SDV]Life Sciences [q-bio] Gastroenterology Disease medicine.disease 3. Good health Lymphoma 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Immune system Immunology Internal Medicine medicine biology.protein Epigenetics Sjogren s business ComputingMilieux_MISCELLANEOUS Epigenomics |
| Zdroj: | La Revue De Médecine Interne La Revue De Médecine Interne, Elsevier, 2017, ⟨10.1016/j.revmed.2017.09.003⟩ |
| ISSN: | 0248-8663 1768-3122 |
| DOI: | 10.1016/j.revmed.2017.09.003 |
| Popis: | Sjogren's syndrome (SS) is a systemic autoimmune epithelitis with a major female incidence, and characterized by a dry syndrome, impaired quality of life, visceral involvement, and lymphoma for the most aggressive cases. During this process, epithelial cells acquire the capacity to produce cytokines, chemokines, and autoantigens which can in turn be presented to the immune system. Consequently, this epithelitis is accompanied by lymphocytic infiltrations leading to the formation of pseudo-follicles in which self-reactive B lymphocytes are present. The recent integration of genomic and especially of epigenomic data, which make it possible to analyze the different cellular partners, opens new perspectives and allows to a better understanding of this complex and still incurable disease. |
| Databáze: | OpenAIRE |
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